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Do (xeno)estrogens pose a risk to earthworms? Soy isoflavones and estradiol impact gonad structure and induce oxidative stress in Eisenia fetida

2025-03-26Artigo científico Acesso aberto
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dc.contributor.authorAzevedo, Tiago
dc.contributor.authorSilva-Reis, Rita
dc.contributor.authorMedeiros-Fonseca, Beatriz
dc.contributor.authorGonçalves, Mariana
dc.contributor.authorMendes, Gabriel
dc.contributor.authorRoboredo, Marta
dc.contributor.authorRocha, Maria J.
dc.contributor.authorPeixoto, Francisco
dc.contributor.authorPinto, Maria de Lurdes
dc.contributor.authorMatos, Manuela
dc.contributor.authorSousa, João R.
dc.contributor.authorOliveira, Paula A.
dc.contributor.authorCoimbra, Ana M.
dc.date.accessioned2026-02-12T11:18:41Z
dc.date.available2026-02-12T11:18:41Z
dc.date.issued2025-03-26
dc.description.abstractUnderstanding the impact of endocrine disruptor compounds (EDCs) across a wide range of species is crucial, given their ubiquitous presence. Although invertebrate species lack sex steroid hormone pathways, they exhibit sensitivity to EDCs, which could affect population dynamics. This study assessed reproductive endpoints and oxidative stress parameters in Eisenia fetida following exposure to estradiol and soy isoflavones, resembling the concentrations found in livestock manure. The experiment used artificial soil, as recommended by OECD guidelines (7:2:1 sand, kaolin and peat). Adult specimens were randomly divided into seven groups (n = 11/replicate): one control, three estradiol (156.1, 283.4 and 633.8 μg/kg of dry soil) and three soy isoflavones (113.0, 215.3 and 405.0 mg/kg of dry soil) concentrations. After eight weeks, samples were collected for cytological, histological and biochemical analysis. Offspring development was assessed after 12 additional weeks. Higher estradiol and isoflavone concentrations led to lower germ cell number and increased abnormalities, especially in the seminal vesicles and ovaries. Catalase and peroxidase activities were significantly increased in all treated groups. The exposure did not significantly affect the number of E. fetida offspring. These findings highlight E. fetida’s sensitivity to EDCs at a biochemical and tissue level, suggesting its use as a bioindicator for assessing EDC contamination in soils.eng
dc.description.abstractHighlights: -No mortality observed in E. fetida after exposure to varying EDC concentrations -Estradiol and soy isoflavones increased catalase and peroxidase enzyme activities. -Germ cell number was reduced and abnormalities increased in reproductive organs. -Reproductive output was not affected, suggesting possible adaptive mechanisms. -This study highlights the need for future research on EDC effects in soil organisms.eng
dc.description.sponsorshipThis work was supported by National Funds by FCT - Portuguese Foundation for Science and Technology, under the projects UIDB/04033/2020 (DOI: 10.54499/UIDB/04033/2020) (CITAB), UIDB/04423/2020 and UIDP/04423/2020 (CIIMAR), support of the ICBAS’ Master of Marine Sciences – Marine Resources, and LA/P/0126/2020 (DOI: 10.54499/LA/P/0126/2020) (INOV4AGRO), Doctoral Grants (2022.14518.BD, Rita Silva-Reis; 2022.13676.BD, Mariana Gonçalves; and 2020.07675.BD, Beatriz Medeiros-Fonseca) and the Grant-in-Aid “Verão com Ciência”, under the file 50/20/7/254 “Curso Prático - Aplicação de modelos biológicos a estudos de ecotoxicologia”. Tiago Azevedo acknowledges the research fellowship with reference BI/UTAD/17/2023 (IAPMEI - PRR - Recovery and Resilience Plan/Mobilising Agendas Reference/C644866286).
dc.identifier.citationChemosphere. 2025 May:377:144315. doi: 10.1016/j.chemosphere.2025.144315. Epub 2025 Mar 26
dc.identifier.doi10.1016/j.chemosphere.2025.144315
dc.identifier.issn0045-6535
dc.identifier.pmid40147346
dc.identifier.urihttp://hdl.handle.net/10400.18/10910
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationCentre for the Research and Technology of Agro-Environmental and Biological Sciences
dc.relationInterdisciplinary Centre of Marine and Environmental Research
dc.relationInterdisciplinary Centre of Marine and Environmental Research
dc.relationUnveiling the potency of Cannabis Sativas active compounds in colorectal cancer
dc.relationInnovative & personalized RNA-based therapies for rare diseases and development of models for their testing: application to Mucolipidosis II
dc.relationNovo: Estudo dos efeitos biológicos de extratos de compostos naturais e suas contribuições para o processo de carcinogénese induzido por papilomavírus. Study of the biologic effects of natural compounds and its contributions to the papillomavirus-induced carcinogenesis process.Inicial:Estudo dos efeitos imunossupressores de Pteridium aquilinum e suas contribuições para o processo de carcinogénese induzido por papilomavírus.
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0045653525002577?via%3Dihub
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectEcotoxicity
dc.subjectEndocrine Disruptor Compounds
dc.subjectHistology
dc.subjectLivestock Manure
dc.subjectOxidative Stress
dc.subjectPhytoestrogens
dc.subjectReproduction
dc.subjectDoenças Genéticas
dc.subjectGenética Humana
dc.titleDo (xeno)estrogens pose a risk to earthworms? Soy isoflavones and estradiol impact gonad structure and induce oxidative stress in Eisenia fetidaeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for the Research and Technology of Agro-Environmental and Biological Sciences
oaire.awardTitleInterdisciplinary Centre of Marine and Environmental Research
oaire.awardTitleInterdisciplinary Centre of Marine and Environmental Research
oaire.awardTitleUnveiling the potency of Cannabis Sativas active compounds in colorectal cancer
oaire.awardTitleInnovative & personalized RNA-based therapies for rare diseases and development of models for their testing: application to Mucolipidosis II
oaire.awardTitleNovo: Estudo dos efeitos biológicos de extratos de compostos naturais e suas contribuições para o processo de carcinogénese induzido por papilomavírus. Study of the biologic effects of natural compounds and its contributions to the papillomavirus-induced carcinogenesis process.Inicial:Estudo dos efeitos imunossupressores de Pteridium aquilinum e suas contribuições para o processo de carcinogénese induzido por papilomavírus.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04033%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04423%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04423%2F2020/PT
oaire.awardURIhttp://hdl.handle.net/10400.18/10908
oaire.awardURIhttp://hdl.handle.net/10400.18/10895
oaire.awardURIhttp://hdl.handle.net/10400.18/10909
oaire.citation.startPage144315
oaire.citation.titleChemosphere
oaire.citation.volume377
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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