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Exposure of gastrointestinal tract to aflatoxin B1: an overlooked impact?

2021-09Conference object Restricted access
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dc.contributor.authorSerrenho, I.
dc.contributor.authorAssunção, R.
dc.contributor.authorAlvito, P.
dc.date.accessioned2021-10-29T18:37:46Z
dc.date.available2021-10-29T18:37:46Z
dc.date.issued2021-09
dc.description.abstractIntroduction: Human exposure to aflatoxin B1 (AFB1) through contaminated food ingestion and its impact on the gastrointestinal tract (GIT) is a field of scientific growing interest. Beyond the recognized carcinogenic potential, AFB1 has the ability to disrupt the intestinal barrier affecting its balance and dynamics, and could promote the development of chronic intestinal inflammation, among other pathologies. These conditions may affect the general population and could constitute a matter of increased concern for vulnerable populations, such as pregnant women and children, especially when AFB1 transfer through the placenta is considered. Since it is expected to occur an increase of AFB1 exposure through food due to climatic change and this could consequently contribute to an increase in number of GIT pathologies, this study aims to raise awareness of health professionals for the potential impact of AFB1 in the GIT and associated health effects. Methodology: The bibliographic search was carried out in 2021, using the Web of Science and PubMed search engines, including specific key words, for the period 2000-2020. From a total of 265 references found, 208 were excluded (duplicates and studies outside the intended context) and 57 were analyzed. Results and Conclusion: The significant impact of AFB1 in the intestinal barrier was evidenced, compromising the intestinal immunity and, consequently, affecting the health of the considered organism. As it becomes increasingly evident that early exposure to chemical contaminants can lead to the onset of diseases in adults such as infections, cancer, diabetes and autoimmune diseases, it is therefore important to develop studies aiming to assess the importance of the environment intrauterine and first years of life in the health of the child and the future adult. The raise of awareness of health professionals of a possible increase in number of GIT pathologies associated to exposure to AFB1 arising from climatic change is therefore crucial to empower health professionals to act based on a deeper scientific knowledge.pt_PT
dc.description.sponsorshipFCT/MCTES funding with national funds related to the earlyMYCO project (PTDC/MEDTOX /28762/2017) andCESAM (UIDP/50017/2020+UIDB/50017/2020). R.A. thanks for the FCT Individual CEEC 2018 Assistant Researcher Grant CEECIND/01570/2018.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7799
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationPTDC/MEDTOX/28762/2017pt_PT
dc.relationCentre for Environmental and Marine Studies
dc.relationCentre for Environmental and Marine Studies
dc.subjectAflatoxin B1pt_PT
dc.subjectExposurept_PT
dc.subjectGastrointestinal Tractpt_PT
dc.subjectComposição dos Alimentospt_PT
dc.subjectSegurança Alimentarpt_PT
dc.subjectToxicologia dos Alimentospt_PT
dc.subjectAvaliação do Riscopt_PT
dc.subjectSaúde Humanapt_PT
dc.titleExposure of gastrointestinal tract to aflatoxin B1: an overlooked impact?pt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardTitleCentre for Environmental and Marine Studies
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50017%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50017%2F2020/PT
oaire.citation.conferencePlace(online)pt_PT
oaire.citation.title4th International Conference on Food Contaminants: Challenges on Early-Life Exposure, 27-28 set 2021pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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relation.isProjectOfPublication0e72e6c8-b610-43e0-931c-8ad275ad6093
relation.isProjectOfPublication.latestForDiscovery0e72e6c8-b610-43e0-931c-8ad275ad6093

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