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Clinical standards for antimicrobial stewardship in TB care

2025-12Artigo científico Acesso aberto
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dc.contributor.authorBrehm, T T
dc.contributor.authorAkkerman, O W
dc.contributor.authorSotgiu, G
dc.contributor.authorTiberi, S
dc.contributor.authorChang, K-C
dc.contributor.authorDheda, K
dc.contributor.authorDuarte, Raquel
dc.contributor.authorVambe, D
dc.contributor.authorUdwadia, Z F
dc.contributor.authorChesov, D
dc.contributor.authorMendelson, M
dc.contributor.authorIswari Saktiawati, A M
dc.contributor.authorvan Ingen, J
dc.contributor.authorEyuboglu, F O
dc.contributor.authorTängdén, T
dc.contributor.authorQuang Vo, L N
dc.contributor.authorRiccardi, N
dc.contributor.authorMoschos, C
dc.contributor.authorFriedland, J S
dc.contributor.authorLillebaek, T
dc.contributor.authorChandy, S J
dc.contributor.authorCaminero, J A
dc.contributor.authorThwaites, G
dc.contributor.authorGandra, S
dc.contributor.authorThursky, K
dc.contributor.authorGeorge, I A
dc.contributor.authorKonstantynovska, O
dc.contributor.authorFatima, R
dc.contributor.authorYim, J-J
dc.contributor.authorKwak, N
dc.contributor.authorOlaru, I D
dc.contributor.authorGillespie, S H
dc.contributor.authorKherabi, Y
dc.contributor.authorPerl, S H
dc.contributor.authorGrønningen, E
dc.contributor.authorRodrigues, C
dc.contributor.authorBjerrum, S
dc.contributor.authorBange, F
dc.contributor.authorCox, V
dc.contributor.authorCirillo, D M
dc.contributor.authorSaluzzo, F
dc.contributor.authorHara, G L
dc.contributor.authorWagner, D
dc.contributor.authorIsmail, N
dc.contributor.authorSloan, D J
dc.contributor.authorEshun-Wilsonova, I
dc.contributor.authorZeng, M
dc.contributor.authorCantero, C
dc.contributor.authorVasankari, T
dc.contributor.authorMandalakas, A
dc.contributor.authorKay, A
dc.contributor.authorNess, T
dc.contributor.authorTorrico, M M
dc.contributor.authorGünther, G
dc.contributor.authorKuksa, L
dc.contributor.authorGuglielmetti, L
dc.contributor.authorGarcía-Basteiro, A L
dc.contributor.authorMarks, G B
dc.contributor.authorPulcini, C
dc.contributor.authorLange, C
dc.date.accessioned2026-02-12T13:09:29Z
dc.date.available2026-02-12T13:09:29Z
dc.date.issued2025-12
dc.description.abstractBackground: While antimicrobial stewardship (AMS) is essential for combating antimicrobial resistance (AMR), TB-specific AMS strategies remain poorly defined. Methods: An international panel of 62 experts participated in a Delphi process. Using a 5-point Likert scale (5 = strong agreement; 1 = strong disagreement), participants evaluated 10 draft clinical standards developed by a core coordination team. A standard was adopted if ≥90% of respondents rated it three or higher, according to a predefined consensus threshold. Results: All 10 standards reached the consensus threshold and were adopted: Standard 1, integration of TB into national AMR action plans; Standard 2, implementation of TB surveillance systems; Standard 3, education of health care providers, individuals affected by TB, and the public; Standard 4, integration of TB into AMS activities; Standard 5, establishment of expert consultation services; Standard 6, targeted testing and preventive treatment for individuals at risk for TB; Standard 7, access to timely and comprehensive drug susceptibility testing; Standard 8, prioritisation of efficacy, safety, and resistance prevention in TB treatment regimens; Standard 9, clinical and microbiological monitoring of treatment response; and Standard 10, assessment of adherence, drug exposure, and resistance in treatment failure. Conclusion: These clinical standards aim to support clinicians, programme managers, and public health authorities in implementing effective, TB-specific AMS strategies.eng
dc.identifier.citationIJTLD Open. 2025 Dec 10;2(12):716-726. doi: 10.5588/ijtldopen.25.0522. eCollection 2025 Dec
dc.identifier.doi10.5588/ijtldopen.25.0522
dc.identifier.eissn3005-7590
dc.identifier.pmid41395320
dc.identifier.urihttp://hdl.handle.net/10400.18/10920
dc.language.isoen
dc.peerreviewedyes
dc.publisherInternational Union Against Tuberculosis and Lung Disease
dc.relation.hasversionhttps://journals.theunion.org/content/ijtldo/2/12/716
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectTuberculosis
dc.subjectAntimicrobial Resistance
dc.subjectDrug Resistance
dc.subjectRifampicin Resistance
dc.subjectInfecções Respiratórias
dc.subjectResistência aos Antimicrobianos
dc.titleClinical standards for antimicrobial stewardship in TB carepor
dc.typejournal article
dcterms.referenceshttps://journals.theunion.org/content/ijtldo/2/12/716/DC1/embed/inline-supplementary-material-1.pdf
dspace.entity.typePublication
oaire.citation.endPage726
oaire.citation.issue12
oaire.citation.startPage716
oaire.citation.titleIJTLD OPEN
oaire.citation.volume2
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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