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Firefighters exposure to fire emissions: Impact on levels of biomarkers of exposure to polycyclic aromatic hydrocarbons and genotoxic/oxidative-effects

2019-09-06Journal article Restricted access
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dc.contributor.authorOliveira, Marta
dc.contributor.authorCosta, Solange
dc.contributor.authorVaz, Josiana
dc.contributor.authorFernandes, Adília
dc.contributor.authorSlezakova, Klara
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorCarmo Pereira, Maria
dc.contributor.authorMorais, Simone
dc.date.accessioned2020-05-08T11:56:34Z
dc.date.available2020-05-08T11:56:34Z
dc.date.issued2019-09-06
dc.description.abstractFirefighters represent one of the riskiest occupations, yet due to the logistic reasons, the respective exposure assessment is one of the most challenging. Thus, this work assessed the impact of firefighting activities on levels of urinary monohydroxyl-polycyclic aromatic hydrocarbons (OHPAHs; 1-hydroxynaphthalene, 1-hydroxyacenaphthene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, 1-hydroxypyrene, 3-hydroxybenzo(a)pyrene) and genotoxic/oxidative-effect biomarkers (basal DNA and oxidative DNA damage) of firefighters from eight firehouses. Cardiac frequency, blood pressure and arterial oxygen saturation were also monitored. OHPAHs were determined by liquid-chromatography with fluorescence detection, while genotoxic/oxidative-effect biomarkers were assessed by the comet assay. Concentrations of total OHPAHs were up to 340% higher (p ≤ 0.05) in (non-smoking and smoking) exposed workers than in control subjects (non-smoking and non-exposed to combat activities); the highest increments were observed for 1-hydroxynaphthalene and 1-hydroxyacenaphthene (82-88% of ∑OHPAHs), and for 2-hydroxyfluorene (5-15%). Levels of biomarker for oxidative stress were increased in non-smoking exposed workers than in control group (316%; p ≤ 0.001); inconclusive results were found for DNA damage. Positive correlations were found between the cardiac frequency, ∑OHPAHs and the oxidative DNA damage of non-smoking (non-exposed and exposed) firefighters. Evidences were raised regarding the simultaneous use of these biomarkers for the surveillance of firefighters' health and to better estimate the potential short-term health risks.pt_PT
dc.description.abstractHighlights: Urinary PAH metabolites and genotoxic/oxidative effects were assessed in firefighters; Levels of total PAH metabolites were increased up to 340% in exposed subjects; Urinary 1OHNaph+1OHAce, and 2OHFlu were the compounds with the highest increments; Firefighting and tobacco smoke raised the oxidative DNA damage in exposed subjects; Cardiac frequency, PAH metabolites and DNA damage can be used for health surveillance.pt_PT
dc.description.sponsorshipThis work received financial support from European (FEDER funds through COMPETE) and National funds through Fundação para a Ciência e Tecnologia for projects UID/QUI/50006/2019 and PCIF/SSO/ 0017/2018, and in the scope of the P2020 Partnership Agreement Project POCI-01-0145-FEDER-006939 (LEPABE). K. Slezakova and S. Costa were supported by the grants SFRH/BPD/105100/2014 and SFRH/BPD/100948/2014, respectively.
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Hazard Mater. 2020 Feb 5;383:121179. doi: 10.1016/j.jhazmat.2019.121179. Epub 2019 Sep 6pt_PT
dc.identifier.doi10.1016/j.jhazmat.2019.121179pt_PT
dc.identifier.issn0304-3894
dc.identifier.urihttp://hdl.handle.net/10400.18/6617
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S0304389419311331?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectDNA Damagept_PT
dc.subjectFirefightingpt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectTobacco Smokingpt_PT
dc.subjectUrinary Monohydroxyl Metabolitespt_PT
dc.subjectAr e Saúde Ocupacionalpt_PT
dc.titleFirefighters exposure to fire emissions: Impact on levels of biomarkers of exposure to polycyclic aromatic hydrocarbons and genotoxic/oxidative-effectspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage121179pt_PT
oaire.citation.titleJournal of Hazardous Materialspt_PT
oaire.citation.volume383pt_PT
rcaap.embargofctDe acordo com política editorial da revista.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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