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High frequency of subclonal ALK mutations in high risk neuroblastoma patients. A SIOPEN study
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Introduction:
In neuroblastoma (NB), activating ALK receptor tyrosine kinase point mutations are
detected in 8–10% at diagnosis using conventional sequencing. To determine the
potential occurrence and the prognostic impact of ALK mutations in a series of high
risk NB patients we studied ALK variation frequencies using targeted deep
sequencing in samples of patients enrolled in the SIOPEN HR-NBL01 study
Descrição
Palavras-chave
Neuroblastoma SIOPEN ALK High Risk Doenças Genéticas