Functional compatibility of PB1 and antigenic proteins as a determinant of viral fitness and adaptation in the A(H1N1)pdm09

Gíria, Marta; Louro, João; Rebelo de Andrade, Helena

http://hdl.handle.net/10400.18/4637

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Authors

Gíria, Marta

Louro, João

Rebelo de Andrade, Helena

Abstract(s)

Objectives: To determine if the functional compatibility between PB1 and antigenic proteins is a molecular determinant of virus growth and antigen yield in PR8:A(H1N1)pdm09 reassortants; To evaluate the phenotypic expression of reverting mutations R386K, I517V and L298I, previously identified as putatively associated with an enhanced functional compatibility between PB1 and HA in the A(H1N1)pdm09