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Predominance of influenza virus A(H3N2) 3C.2a1b and A(H1N1)pdm09 6B.1A5A genetic subclades in the WHO European Region, 2018–2019

2020-07-31Journal article Open access
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dc.contributor.authorMelidou, Angeliki
dc.contributor.authorHungnes, Olav
dc.contributor.authorPereyaslov, Dmitriy
dc.contributor.authorAdlhoch, Cornelia
dc.contributor.authorSegaloff, Hannah
dc.contributor.authorRobesyn, Emmanuel
dc.contributor.authorPenttinen, Pasi
dc.contributor.authorOlsen, Sonja J.
dc.contributor.authorRedlberger-Fritz, Monika
dc.contributor.authorPopow-Kraupp, Therese
dc.contributor.authorHasibra, Iris
dc.contributor.authorSimaku, Artan
dc.contributor.authorThomas, Isabelle
dc.contributor.authorBarbezange, Cyril
dc.contributor.authorDedeić-Ljubović, Amela
dc.contributor.authorRodić-Vukmir, Nina
dc.contributor.authorKorsun, Neli
dc.contributor.authorAngenova, Svetla
dc.contributor.authorDraženović, Vladimir
dc.contributor.authorKoliou, Maria
dc.contributor.authorPieridou, Despo
dc.contributor.authorHavlickova, Martina
dc.contributor.authorNagy, Alexander
dc.contributor.authorTrebbien, Ramona
dc.contributor.authorGaliano, Monica
dc.contributor.authorThompson, Catherine
dc.contributor.authorIkonen, Niina
dc.contributor.authorHaveri, Anu
dc.contributor.authorBehillil, Sylvie
dc.contributor.authorEnouf, Vincent
dc.contributor.authorValette, Martine
dc.contributor.authorLina, Bruno
dc.contributor.authorGavashelidze, Mari
dc.contributor.authorMachablishvili, Ann
dc.contributor.authorGioula, Georgia
dc.contributor.authorExindari, Maria
dc.contributor.authorKossyvakis, Athanasios
dc.contributor.authorMentis, Andreas
dc.contributor.authorDürrwald, Ralf
dc.contributor.authorZsuzsanna, Molnar
dc.contributor.authorMonika, Rozsa
dc.contributor.authorLöve, Arthur
dc.contributor.authorErna, Gudrun
dc.contributor.authorDunford, Linda
dc.contributor.authorFitzpatrick, Sarah
dc.contributor.authorCastrucci, Maria Rita
dc.contributor.authorPuzelli, Simona
dc.contributor.authorSagymbay, Altynay
dc.contributor.authorNussupbayeva, Gaukhar
dc.contributor.authorZamjatina, Natalija
dc.contributor.authorPakarna, Gatis
dc.contributor.authorGriskevičius, Algirdas
dc.contributor.authorSkrickiene, Asta
dc.contributor.authorFournier, Guillaume
dc.contributor.authorMossong, Joel
dc.contributor.authorMelillo, Jackie
dc.contributor.authorZahra, Graziella
dc.contributor.authorMeijer, Adam
dc.contributor.authorFouchier, Ron
dc.contributor.authorMcCaughey, Conall
dc.contributor.authorO'Doherty, Mark
dc.contributor.authorBragstad, Karoline
dc.contributor.authorGuiomar, Raquel
dc.contributor.authorPechirra, Pedro
dc.contributor.authorApostol, Mariana
dc.contributor.authorAlina, Druc
dc.contributor.authorLazar, Mihaela
dc.contributor.authorMaria, Cherciu Carmen
dc.contributor.authorKomissarov, Andrey
dc.contributor.authorBurtseva, Elena
dc.contributor.authorGunson, Rory N.
dc.contributor.authorShepherd, Samantha
dc.contributor.authorTichá, Elena
dc.contributor.authorStaronova, Edita
dc.contributor.authorProsenc, Katarina
dc.contributor.authorBerginc, Nataša
dc.contributor.authorPozo, Francisco
dc.contributor.authorCasas, Inmaculada
dc.contributor.authorBrytting, Mia
dc.contributor.authorWiman, Åsa
dc.contributor.authorGonçalves, Ana Rita
dc.contributor.authorDemchyshyna, Iryna
dc.contributor.authorMironenko, Alla
dc.contributor.authorMoore, Catherine
dc.contributor.authorCottrell, Simon
dc.contributor.authorEuropean Region influenza surveillance network
dc.date.accessioned2021-04-02T16:36:46Z
dc.date.available2021-04-02T16:36:46Z
dc.date.issued2020-07-31
dc.descriptionNetwork authors: Portugal - Raquel Guiomar, Pedro Pechirra, National Influenza Reference Laboratory, Infectious Diseases Department, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugalpt_PT
dc.description.abstractBackground: The 2018/2019 influenza season in the WHO European Region was dominated by influenza A (H1N1)pdm09 and (H3N2) viruses, with very few influenza B viruses detected. Methods: Countries in the European Region reported virus characterization data to The European Surveillance System for weeks 40/2018 to 20/2019. These virus antigenic and genetic characterization and haemagglutinin (HA) sequence data were analysed to describe and assess circulating viruses relative to the 2018/2019 vaccine virus components for the northern hemisphere. Results: Thirty countries reported 4776 viruses characterized genetically and 3311 viruses antigenically. All genetically characterized A(H1N1)pdm09 viruses fell in subclade 6B.1A, of which 90% carried the amino acid substitution S183P in the HA gene. Antigenic data indicated that circulating A(H1N1)pdm09 viruses were similar to the 2018/2019 vaccine virus. Genetic data showed that A(H3N2) viruses mostly fell in clade 3C.2a (75%) and 90% of which were subclade 3C.2a1b. A lower proportion fell in clade 3C.3a (23%) and were antigenically distinct from the vaccine virus. All B/Victoria viruses belonged to clade 1A; 30% carried a double amino acid deletion in HA and were genetically and antigenically similar to the vaccine virus component, while 55% carried a triple amino acid deletion or no deletion in HA; these were antigenically distinct from each other and from the vaccine component. All B/Yamagata viruses belonged to clade 3 and were antigenically similar to the virus component in the quadrivalent vaccine for 2018/2019. Conclusions: A simultaneous circulation of genetically and antigenically diverse A(H3N2) and B/Victoria viruses was observed and represented a challenge to vaccine strain selection.pt_PT
dc.description.abstractHighlights: Co-circulation of different clades/subclades of influenza A viruses in 2018/2019 in the Region; Most circulating A(H1N1)pdm09 viruses (6B.1A) carried S183P in hemagglutinin; Genetically heterogeneous A(H3N2) viruses, with co-circulation of clades 3C.2a and 3C.3a; Antigenically distinct A(H3N2) clade 3C.3a viruses were increasingly detected until 02/2019 and then decreased; Co-circulation of genetically and antigenically diverse A(H3N2) strains challenges vaccine strain selection.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVaccine. 2020 Jul 31;38(35):5707-5717. doi: 10.1016/j.vaccine.2020.06.031. Epub 2020 Jul 3.pt_PT
dc.identifier.doi10.1016/j.vaccine.2020.06.031pt_PT
dc.identifier.issn0264-410X
dc.identifier.urihttp://hdl.handle.net/10400.18/7630
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0264410X20308045?via%3Dihubpt_PT
dc.subjectAntigenicpt_PT
dc.subjectEuropept_PT
dc.subjectGeneticpt_PT
dc.subjectInfluenzapt_PT
dc.subjectSurveillancept_PT
dc.subjectVaccinept_PT
dc.subjectInfecções Respiratóriaspt_PT
dc.titlePredominance of influenza virus A(H3N2) 3C.2a1b and A(H1N1)pdm09 6B.1A5A genetic subclades in the WHO European Region, 2018–2019pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage5717pt_PT
oaire.citation.issue35pt_PT
oaire.citation.startPage5707pt_PT
oaire.citation.titleVaccinept_PT
oaire.citation.volume38pt_PT
rcaap.embargofctAcesso de acordo com página web do editor da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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