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Posttranscriptional Regulation of Splicing Factor SRSF1 and Its Role in Cancer Cell Biology

2015-07Journal article Open access
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dc.contributor.authorGonçalves, Vânia
dc.contributor.authorJordan, Peter
dc.date.accessioned2016-02-17T17:51:44Z
dc.date.available2016-02-17T17:51:44Z
dc.date.issued2015-07
dc.description.abstractOver the past decade, alternative splicing has been progressively recognized as a major mechanism regulating gene expression patterns in different tissues and disease states through the generation of multiple mRNAs from the same gene transcript. This process requires the joining of selected exons or usage of different pairs of splice sites and is regulated by gene-specific combinations of RNA-binding proteins. One archetypical splicing regulator is SRSF1, for which we review the molecular mechanisms and posttranscriptional modifications involved in its life cycle. These include alternative splicing of SRSF1 itself, regulatory protein phosphorylation events, and the role of nuclear versus cytoplasmic SRSF1 localization. In addition, we resume current knowledge on deregulated SRSF1 expression in tumors and describe SRSF1-regulated alternative transcripts with functional consequences for cancer cell biology at different stages of tumor development.pt_PT
dc.identifier.citationBiomed Res Int. 2015;2015:287048. doi: 10.1155/2015/287048. Epub 2015 Jul 26pt_PT
dc.identifier.doi10.1155/2015/287048pt_PT
dc.identifier.issn2314-6133
dc.identifier.urihttp://hdl.handle.net/10400.18/3393
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherHindawi Publishing Corporationpt_PT
dc.relation.publisherversionhttp://www.hindawi.com/journals/bmri/2015/287048/pt_PT
dc.subjectVias de Transdução de Sinal e Patologias Associadaspt_PT
dc.subjectSplicing Alternativopt_PT
dc.subjectRNApt_PT
dc.subjectSRSF1pt_PT
dc.subjectCancropt_PT
dc.titlePosttranscriptional Regulation of Splicing Factor SRSF1 and Its Role in Cancer Cell Biologypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleBioMed Research Internationalpt_PT
oaire.citation.volume2015pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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