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High throughput toxicity screening and intracellular detection of nanomaterials

2016-06-07Journal article Open access
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dc.contributor.authorCollins, A.R.
dc.contributor.authorAnnangi, B.
dc.contributor.authorRubio, L.
dc.contributor.authorMarcos, R.
dc.contributor.authorDorn, M.
dc.contributor.authorMerker, C.
dc.contributor.authorEstrela-Lopis, I.
dc.contributor.authorCimpan, M.R.
dc.contributor.authorIbrahim, M.
dc.contributor.authorCimpan, E.
dc.contributor.authorOstermann, M.
dc.contributor.authorSauter, A.
dc.contributor.authorYamani, N.E.
dc.contributor.authorShaposhnikov, S.
dc.contributor.authorChevillard, S.
dc.contributor.authorPaget, V.
dc.contributor.authorGrall, R.
dc.contributor.authorDelic, J.
dc.contributor.authorde-Cerio, F.G.
dc.contributor.authorSuarez-Merino, B.
dc.contributor.authorFessard, V.
dc.contributor.authorHogeveen, K.N.
dc.contributor.authorFjellsbø, L.M.
dc.contributor.authorPran, E.R.
dc.contributor.authorBrzicova, T.
dc.contributor.authorTopinka, J.
dc.contributor.authorSilva, M.J.
dc.contributor.authorLeite, P.E.
dc.contributor.authorRibeiro, A.R.
dc.contributor.authorGranjeiro, J.M.
dc.contributor.authorGrafström, R.
dc.contributor.authorPrina-Mello, A.
dc.contributor.authorDusinska, M.
dc.date.accessioned2017-03-03T18:04:16Z
dc.date.available2017-03-03T18:04:16Z
dc.date.issued2016-06-07
dc.descriptionEC FP7 NANoREG (Grant Agreement NMP4-LA-2013-310584)pt_PT
dc.descriptionFree PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215403/pt_PT
dc.description.abstractWith the growing numbers of nanomaterials (NMs), there is a great demand for rapid and reliable ways of testing NM safety—preferably using in vitro approaches, to avoid the ethical dilemmas associated with animal research. Data are needed for developing intelligent testing strategies for risk assessment of NMs, based on grouping and read-across approaches. The adoption of high throughput screening (HTS) and high content analysis (HCA) for NM toxicity testing allows the testing of numerous materials at different concentrations and on different types of cells, reduces the effect of inter-experimental variation, and makes substantial savings in time and cost.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationWiley Interdiscip Rev Nanomed Nanobiotechnol. 2017 Jan;9(1). doi: 10.1002/wnan.1413. Epub 2016 Jun 7pt_PT
dc.identifier.doi10.1002/wnan.1413pt_PT
dc.identifier.issn1939-5116
dc.identifier.urihttp://hdl.handle.net/10400.18/4466
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWiley/WIREs Nanomedicine and Nanobiotechnologypt_PT
dc.relationA common European approach to the regulatory testing of nanomaterials
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/wnan.1413/abstract;jsessionid=8F9D718C32F96212BC4FEEFE49BB8568.f03t02pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectNanotoxicologypt_PT
dc.subjectHigh Throughputpt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleHigh throughput toxicity screening and intracellular detection of nanomaterialspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleA common European approach to the regulatory testing of nanomaterials
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/310584/EU
oaire.citation.issue1pt_PT
oaire.citation.titleWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnologypt_PT
oaire.citation.volume9pt_PT
oaire.fundingStreamFP7
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationf9fe5c15-606f-4958-ac4b-8109981d34c7
relation.isProjectOfPublication.latestForDiscoveryf9fe5c15-606f-4958-ac4b-8109981d34c7

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