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Low 2018/19 vaccine effectiveness against influenza A(H3N2) among 15-64-year-olds in Europe: exploration by birth cohort

2019-11-28Journal article Open access
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dc.contributor.authorKissling, Esther
dc.contributor.authorPozo, Francisco
dc.contributor.authorBuda, Silke
dc.contributor.authorVilcu, Ana-Maria
dc.contributor.authorGherasim, Alin
dc.contributor.authorBrytting, Mia
dc.contributor.authorDomegan, Lisa
dc.contributor.authorGómez, Verónica
dc.contributor.authorMeijer, Adam
dc.contributor.authorLazar, Mihaela
dc.contributor.authorVučina, Vesna Višekruna
dc.contributor.authorDürrwald, Ralf
dc.contributor.authorvan der Werf, Sylvie
dc.contributor.authorLarrauri, Amparo
dc.contributor.authorEnkirch, Theresa
dc.contributor.authorO’Donnell, Joan
dc.contributor.authorGuiomar, Raquel
dc.contributor.authorHooiveld, Mariëtte
dc.contributor.authorPetrović, Goranka
dc.contributor.authorStoian, Elena
dc.contributor.authorPenttinen, Pasi
dc.contributor.authorValenciano, Marta
dc.contributor.authorI-MOVE primary care study team
dc.date.accessioned2020-04-27T19:02:18Z
dc.date.available2020-04-27T19:02:18Z
dc.date.issued2019-11-28
dc.descriptionI-MOVE primary care study team (Portugal): Ana Paula Rodrigues, Ausenda Machado, Baltazar Nunes, Irina Kislaya, Inês Costa, Patrícia Conde, Paula Cristóvão, Pedro Pechirra, Vítor Borgespt_PT
dc.description.abstractIntroduction: Influenza A(H3N2) clades 3C.2a and 3C.3a co-circulated in Europe in 2018/19. Immunological imprinting by first childhood influenza infection may induce future birth cohort differences in vaccine effectiveness (VE). Aim: The I-MOVE multicentre primary care test-negative study assessed 2018/19 influenza A(H3N2) VE by age and genetic subgroups to explore VE by birth cohort. Methods: We measured VE against influenza A(H3N2) and (sub)clades. We stratified VE by usual age groups (0–14, 15–64, ≥ 65-years). To assess the imprint-regulated effect of vaccine (I-REV) hypothesis, we further stratified the middle-aged group, notably including 32–54-year-olds (1964–86) sharing potential childhood imprinting to serine at haemagglutinin position 159. Results: Influenza A(H3N2) VE among all ages was −1% (95% confidence interval (CI): −24 to 18) and 46% (95% CI: 8–68), −26% (95% CI: −66 to 4) and 20% (95% CI: −20 to 46) among 0–14, 15–64 and ≥ 65-year-olds, respectively. Among 15–64-year-olds, VE against clades 3C.2a1b and 3C.3a was 15% (95% CI: −34 to 50) and −74% (95% CI: −259 to 16), respectively. VE was −18% (95% CI: −140 to 41), −53% (95% CI: −131 to −2) and −12% (95% CI: −74 to 28) among 15–31-year-olds (1987–2003), 32–54-yearolds (1964–86) and 55–64-year-olds (1954–63), respectively. Discussion: The lowest 2018/19 influenza A(H3N2) VE was against clade 3C.3a and among those born 1964–86, corresponding to the I-REV hypothesis. The low influenza A(H3N2) VE in 15–64-year-olds and the public health impact of the I-REV hypothesis warrant further study.pt_PT
dc.description.sponsorshipECDCpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEuro Surveill. 2019 Nov;24(48):1900604. doi: 10.2807/1560-7917.ES.2019.24.48.1900604pt_PT
dc.identifier.doi10.2807/1560-7917.ES.2019.24.48.1900604pt_PT
dc.identifier.issn1560-7917
dc.identifier.urihttp://hdl.handle.net/10400.18/6536
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherEuropean Centre for Disease Prevention and Controlpt_PT
dc.relation.publisherversionhttps://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2019.24.48.1900604pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/pt_PT
dc.subjectInfluenzapt_PT
dc.subjectA(H3N2)pt_PT
dc.subjectImprintingpt_PT
dc.subjectDeterminantes de Saúde e Doençapt_PT
dc.subjectEstado de Saúde e Doençapt_PT
dc.subjectGripept_PT
dc.subjectVacina Antigripalpt_PT
dc.subjectEuroEVApt_PT
dc.subjectEfetividadept_PT
dc.subjectÉpoca 2018-2019pt_PT
dc.titleLow 2018/19 vaccine effectiveness against influenza A(H3N2) among 15-64-year-olds in Europe: exploration by birth cohortpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue48pt_PT
oaire.citation.startPage1900604pt_PT
oaire.citation.titleEurosurveillancept_PT
oaire.citation.volume24pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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