Publication
Mapping the Quantitative Dose–Response Relationships Between Nutrients and Health Outcomes to Inform Food Risk–Benefit Assessment
| datacite.subject.fos | Ciências Médicas::Ciências da Saúde | |
| datacite.subject.fos | Ciências Agrárias::Outras Ciências Agrárias | |
| datacite.subject.sdg | 02:Erradicar a Fome | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| dc.contributor.author | Mateus, Gabriel | |
| dc.contributor.author | Ferreira-Pêgo, Cíntia | |
| dc.contributor.author | Assunção, Ricardo | |
| dc.date.accessioned | 2026-01-09T16:21:52Z | |
| dc.date.available | 2026-01-09T16:21:52Z | |
| dc.date.issued | 2025-04-20 | |
| dc.description | (This article belongs to the Special Issue Food Choice, Nutrition, and Public Health: 2nd Edition) | |
| dc.description.abstract | In the context of the global food system transformation towards sustainable and healthy diets, risk–benefit assessment supported by quantitative dose–response relationships between nutrients and health outcomes is crucial for evaluating the public health impact of dietary modifications, particularly those involving novel foods. The primary aim of this review was to establish a foundational basis for RBA by compiling and synthesising quantitative dose–response relationships identified through a comprehensive literature review. This review encompassed the last 15 years up to March 2025, utilising databases such as PubMed, Scopus, and Web of Science. This review prioritised recent meta-analyses of observational studies and randomised controlled trials with a low risk of bias, as assessed using the ROBIS tool. This review identified significant dose–response relationships across 12 nutrients and their associations with various health outcomes. While dietary fibre has demonstrated broad protective effects, cereal fibre has been found to be the most beneficial for colorectal cancer prevention. Calcium has been shown to have inverse associations with several cancers, although high dairy intake may increase the risk of prostate cancer. Haem iron was linked to an increased risk of several chronic diseases, whereas non-haem iron showed less consistent associations. Zinc exhibited a potential U-shaped relationship with colorectal cancer risk. These findings underscore the complexity of nutrient–health relationships, highlighting the importance of considering dose–response gradients and nutrient sources. Although this overview primarily summarises quantitative associations without exploring in-depth mechanistic or population-specific details, it underscores the complexity of nutrient effects, including nonlinearity and source dependency. This analysis offers a valuable foundation for future risk–benefit assessments of various food scenarios, thereby informing dietary recommendations and public health strategies. | eng |
| dc.description.sponsorship | This work was financially supported by “InsectERA” (Project No. C644917393-00000032) within the WPs InFood and One Health, funded by Next Generation EU European Fund and the Portuguese Recovery and Resilience Plan (PRR), under the scope of the incentive line “Agendas for Business Innovation” through the funding scheme C5—Capitalization and Business Innovation. | |
| dc.identifier.citation | Foods. 2025 Apr 20;14(8):1420. doi: 10.3390/foods14081420 | |
| dc.identifier.doi | 10.3390/foods14081420 | |
| dc.identifier.eissn | 2304-8158 | |
| dc.identifier.pmid | 40282821 | |
| dc.identifier.uri | http://hdl.handle.net/10400.18/10677 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | MDPI | |
| dc.relation | C644917393-00000032 | |
| dc.relation.hasversion | https://www.mdpi.com/2304-8158/14/8/1420 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Dietary Modifications | |
| dc.subject | Novel Foods | |
| dc.subject | Health Outcomes | |
| dc.subject | Nutrient Dose–Response | |
| dc.subject | Risk–Benefit Assessment | |
| dc.subject | Nutrição Aplicada | |
| dc.subject | Composição dos Alimentos | |
| dc.subject | Avaliação do Risco | |
| dc.subject | Estilos de Vida e Impacto na Saúde | |
| dc.title | Mapping the Quantitative Dose–Response Relationships Between Nutrients and Health Outcomes to Inform Food Risk–Benefit Assessment | eng |
| dc.type | journal article | |
| dcterms.references | https://www.mdpi.com/article/10.3390/foods14081420/s1 | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 8 | |
| oaire.citation.startPage | 1420 | |
| oaire.citation.title | Foods | |
| oaire.citation.volume | 14 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
| person.familyName | Assunção | |
| person.givenName | Ricardo | |
| person.identifier | 481718 | |
| person.identifier.ciencia-id | 5B1D-9EB4-E1D4 | |
| person.identifier.orcid | 0000-0002-4375-0456 | |
| person.identifier.rid | E-2738-2014 | |
| person.identifier.scopus-author-id | 56330129500 | |
| relation.isAuthorOfPublication | e69f935e-bb21-495a-b274-35d2e945648c | |
| relation.isAuthorOfPublication.latestForDiscovery | e69f935e-bb21-495a-b274-35d2e945648c |