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Tuberculosis across the seas: CPLP-TB - a joint effort in cataloguing mycobacterium tuberculosis genetic diversity in the lusophone space

2017-04-19Lecture Open access
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dc.contributor.authorPerdigão, João
dc.contributor.authorSilva, Carla
dc.contributor.authorDiniz, Jaciara
dc.contributor.authorPereira, Catarina
dc.contributor.authorMachado, Diana
dc.contributor.authorRamos, Jorge
dc.contributor.authorda Silva, Fernanda
dc.contributor.authorBrum, Clarice
dc.contributor.authorReis, Ana J.
dc.contributor.authorMacedo, Maíra
dc.contributor.authorScaini, João L.
dc.contributor.authorSilva, Ana B
dc.contributor.authorEsteves, Leonardo
dc.contributor.authorMacedo, Rita
dc.contributor.authorClemente, Sofia
dc.contributor.authorCoelho, Elizabeth
dc.contributor.authorViegas, Sofia
dc.contributor.authorRabna, Paulo
dc.contributor.authorRodrigues, Amabélia
dc.contributor.authorTaveira, Nuno
dc.contributor.authorJordao, Luisa
dc.contributor.authorCouto, Isabel
dc.contributor.authorvon Groll, Andrea
dc.contributor.authorDalla-Costa, Elis R.
dc.contributor.authorRossetti, Maria Lúcia
dc.contributor.authorda Silva, Pedro E. A.
dc.contributor.authorViveiros, Miguel
dc.contributor.authorPortugal, Isabel
dc.date.accessioned2017-07-05T16:01:06Z
dc.date.available2017-07-05T16:01:06Z
dc.date.issued2017-04-19
dc.description.abstractThe Community of Portuguese Language Speaking Countries (CPLP) comprises nine countries across four continents, accounting for 7.2% of the world’s land area, and where tuberculosis (TB) is still a cause of public health concern. A marked variation in TB incidence (23 to 551 cases per 100 000 habitants) can be observed across the different member-states and, despite of this, a considerable gap in the knowledge on the Mycobacterium tuberculosis population structure and country-level geospatial distribution still exists. To address this we have gathered a comprehensive set of molecular and phenotypic drug susceptibility data on approximately 1150 different clinical isolates, from different partners, across 5 distinct portuguesespeaking countries. This initial dataset comprises molecular genotypic data obtained by either 12, 15 or 24-loci Mycobacterial Interspersed Repetitive Unit – Variable Number of Tandem repeat (MIRU-VNTR) and/or Spoligotyping. The complete dataset therefore includes M. tuberculosis clinical isolates from Portugal (n≈370), Angola (n≈80), Guinea-Bissau (n≈13), Mozambique (n≈14) and Brazil (n≈680). To make this data available to the scientific community and public health authorities we have developed CPLP-TB, an online database coupled with webbased tools that enable exploratory data analysis. This new tool specifically directed at CPLP countries include advanced data analysis capability together with graphical visualization tools (e.g. dendrogram and choropleth mapping). As a public health tool, it is expected to contribute for a deeper knowledge on the combined population structure and strain circulation between countries, thus enabling the assessment of strain specific trends in a broader macroepidemiological context. Furthermore, this new tool provides a new framework for interlaboratory cooperation on TB molecular epidemiology.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/4737
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttp://4cnmt.admeus.net/uploads/4cnmt/editor/Programa_4CNMT_060417.pdfpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectMycobacterium tuberculosispt_PT
dc.subjectTuberculosispt_PT
dc.subjectNGSpt_PT
dc.subjectPortuguese Language Speaking Countriespt_PT
dc.titleTuberculosis across the seas: CPLP-TB - a joint effort in cataloguing mycobacterium tuberculosis genetic diversity in the lusophone spacept_PT
dc.typelecture
dspace.entity.typePublication
oaire.citation.conferencePlaceLisboa, Portugalpt_PT
oaire.citation.title4º Congresso Nacional de Medicina Tropical e o 1º Encontro Lusófono de SIDA, Tuberculose e Doenças Oportunistas, 19-21 abril 2017pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typelecturept_PT

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