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Integrative network analysis for identification of new proteins involved in NMD or its regulation
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Orientador(es)
Resumo(s)
Background: Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and
selectively degrades mRNAs carrying premature translation termination codons (PTCs).
NMD has been associated with many genetic diseases and some forms of cancer caused by
nonsense or frameshift mutations that introduce PTCs.
NMD is a complex process that relies on the involvement of numerous players which interact
with each other in a highly organized manner. However, the interactions and connectivity
among these components is only partly elucidated.
Recent studies have shown that NMD is also involved in the regulation of apparently “normal”
transcripts, suggesting a greater role in gene expression regulation.
Descrição
Palavras-chave
Nonsense-mediated mRNA Decay (NMD) mRNA Metabolism Expressão Génica Genómica Funcional e Estrutural