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Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies

2022-08-17Journal article Open access
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dc.contributor.authorPoteser, Michael
dc.contributor.authorLaguzzi, Federica
dc.contributor.authorSchettgen, Thomas
dc.contributor.authorVogel, Nina
dc.contributor.authorWeber, Till
dc.contributor.authorZimmermann, Philipp
dc.contributor.authorHahn, Domenica
dc.contributor.authorKolossa-Gehring, Marike
dc.contributor.authorNamorado, Sónia
dc.contributor.authorVan Nieuwenhuyse, An
dc.contributor.authorAppenzeller, Brice
dc.contributor.authorHalldorsson, Thorhallur
dc.contributor.authorEiríksdóttir, Ása
dc.contributor.authorHaug, Line Småstuen
dc.contributor.authorThomsen, Cathrine
dc.contributor.authorBarbone, Fabio
dc.contributor.authorRosolen, Valentina
dc.contributor.authorRAMBAUD, Loic
dc.contributor.authorRIOU, Margaux
dc.contributor.authorGöen, Thomas
dc.contributor.authorNübler, Stefanie
dc.contributor.authorSchäfer, Moritz
dc.contributor.authorHaji-Abbas-Zarrabi, Karin
dc.contributor.authorGilles, Liese
dc.contributor.authorRodriguez Martin, Laura
dc.contributor.authorSchoeters, Greta
dc.contributor.authorSepai, Ovnair
dc.contributor.authorGovarts, Eva
dc.contributor.authorMoshammer, Hanns
dc.date.accessioned2022-11-15T12:38:10Z
dc.date.available2022-11-15T12:38:10Z
dc.date.issued2022-08-17
dc.descriptionThis article belongs to the Special Issue Analysis of Human Biomonitoring Data and Risk Assessment of Human Exposure to Environmental Chemicals: What Do We Learn for Prevention?
dc.description.abstractMore than 20 years ago, acrylamide was added to the list of potential carcinogens found in many common dietary products and tobacco smoke. Consequently, human biomonitoring studies investigating exposure to acrylamide in the form of adducts in blood and metabolites in urine have been performed to obtain data on the actual burden in different populations of the world and in Europe. Recognizing the related health risk, the European Commission responded with measures to curb the acrylamide content in food products. In 2017, a trans-European human biomonitoring project (HBM4EU) was started with the aim to investigate exposure to several chemicals, including acrylamide. Here we set out to provide a combined analysis of previous and current European acrylamide biomonitoring study results by harmonizing and integrating different data sources, including HBM4EU aligned studies, with the aim to resolve overall and current time trends of acrylamide exposure in Europe. Data from 10 European countries were included in the analysis, comprising more than 5500 individual samples (3214 children and teenagers, 2293 adults). We utilized linear models as well as a non-linear fit and breakpoint analysis to investigate trends in temporal acrylamide exposure as well as descriptive statistics and statistical tests to validate findings. Our results indicate an overall increase in acrylamide exposure between the years 2001 and 2017. Studies with samples collected after 2018 focusing on adults do not indicate increasing exposure but show declining values. Regional differences appear to affect absolute values, but not the overall time-trend of exposure. As benchmark levels for acrylamide content in food have been adopted in Europe in 2018, our results may imply the effects of these measures, but only indicated for adults, as corresponding data are still missing for children.pt_PT
dc.description.sponsorshipThis work has received external funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 733032 and received co-funding from the author’s organizations. The Norwegian Institute of Public Health (NIPH) has contributed to the funding of the Norwegian Environmental Biobank (NEB). The laboratory measurements have partly been funded by the Research Council of Norway through research projects (275903 and 268465).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationToxics. 2022 Aug 17;10(8):481. doi: 10.3390/toxics10080481pt_PT
dc.identifier.doi10.3390/toxics10080481pt_PT
dc.identifier.issn2305-6304
dc.identifier.urihttp://hdl.handle.net/10400.18/8312
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.relation.publisherversionhttps://www.mdpi.com/2305-6304/10/8/481pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAcrylamidept_PT
dc.subjectGlycidamidept_PT
dc.subjectExposure Levelpt_PT
dc.subjectTime-trendpt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectAcrilamidapt_PT
dc.subjectNível de Exposiçãopt_PT
dc.subjectBiomonitorização Humanapt_PT
dc.subjectDeterminantes da Saúde e da Doençapt_PT
dc.titleTime Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.issue8pt_PT
oaire.citation.startPage481pt_PT
oaire.citation.titleToxicspt_PT
oaire.citation.volume10pt_PT
oaire.fundingStreamH2020
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person.givenNameEva
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person.identifier466597
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project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
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