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Oral Exposure to TiO2 and Cellulose Nanomaterials: review of hazard identification in the adverse outcome pathway landscape

2022-09-24Conference object Restricted access
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dc.contributor.authorRolo, Dora
dc.contributor.authorVital, Nádia
dc.contributor.authorSilva, Maria Raquel
dc.contributor.authorLouro, Henriqueta
dc.date.accessioned2022-11-28T11:18:01Z
dc.date.available2022-11-28T11:18:01Z
dc.date.issued2022-09-24
dc.description.abstractSeveral products in the global market have been improved using titanium dioxide nanomaterials (TiO2 NMs), and many other NMs under development, e.g., cellulose NMs(CNMs), with potential for use in agriculture, food, and feed industries. Despite being considered key enabling technologies, the exponential use of NMs in food technology leads to concerns about adverse health outcomes upon ingestion, such as potential genotoxicity and cancer of the gastrointestinal tract (GIT) due to their bioaccumulation. The aim of this study, considering oral exposure to TiO2 NMs and CNMs as case studies, was to explore the knowledge about these NMs’ cellular and molecular mechanisms of action that may be central to their predicted adverse outcomes pathways at the GIT. For this purpose, literature reviews were setup to target the hazard of these NMs in the GIT context, directed to identify the molecular initiating event (MIE) and key events (KE) that mediate potential genotoxic and carcinogenic effects, thus contributing to Adverse Outcome Pathways (AOP) landscape. From the review of in vitro/in vivo studies, the suggested MIE involves the cellular uptake by intestinal cells and effects at lysosomal level. Several possible KE like inflammation, persistent cell injury/cell death, ROS generation, and DNA damage that may mediate the formation of adenomas/carcinomas were identified for TiO2 NMs; the information for CNMs is scarce. Some knowledge gaps were also identified, opening new avenues for more mechanistic research that will feed into AOPs.pt_PT
dc.description.sponsorshipFCT/MCTES projects PTDC/SAU-PUB/29481/2017; PTDC/SAU-PUB/32587/2017; UIDB/00009/2020; UIDP/ 00009/2020. Nádia Vital holds a FCT/MCTES PhD Scholarship grant (2020.07168.BD).pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/8335
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationA predictive toxicology approach to characterize potential respiratory effects of functionalized nanocellulose fibres in a co-culture system
dc.relationCentre for Toxicogenomics and Human Health
dc.relationCentre for Toxicogenomics and Human Health
dc.relationToxicological profile of cellulose nanomaterials in human gastrointestinal cells
dc.subjectAdverse Outcome Pathwayspt_PT
dc.subjectNanomaterialspt_PT
dc.subjectTiatnium dioxide nanomaterialspt_PT
dc.subjectCellulose Nanomaterialspt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleOral Exposure to TiO2 and Cellulose Nanomaterials: review of hazard identification in the adverse outcome pathway landscapept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleA predictive toxicology approach to characterize potential respiratory effects of functionalized nanocellulose fibres in a co-culture system
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardTitleToxicological profile of cellulose nanomaterials in human gastrointestinal cells
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-PUB%2F29481%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-PUB%2F32587%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00009%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00009%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2020.07168.BD/PT
oaire.citation.conferencePlaceLisboa, Portugalpt_PT
oaire.citation.titleAnnual Meeting International Society of Exposure Science (ISES), 25-29 september 2022pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameVital
person.familyNameSilva
person.familyNameLouro
person.givenNameNádia
person.givenNameMaria Raquel
person.givenNameHenriqueta
person.identifier157627
person.identifier.ciencia-id2518-6117-FB25
person.identifier.ciencia-id721D-2BB1-7DB1
person.identifier.orcid0000-0002-3391-0268
person.identifier.orcid0000-0001-8170-3119
person.identifier.orcid0000-0001-9744-7332
person.identifier.scopus-author-id56924197900
person.identifier.scopus-author-id6507971479
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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