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Publication
Toxicological Assessment of Process-related mycotoxins at a Regulatory Level – state of the art
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Abstract(s)
In the context of food safety, risk assessment (RA) is a conceptual framework that aims to estimate the risk of occurrence of adverse health effects after exposure to mycotoxins present in food. Traditionally, risk assessments are conducted on an individual chemical basis, mostly addressing one source of exposure (single chemical and one route of exposure). However, the human population and the environment are continuously exposed to a multitude of mycotoxins from different sources via different routes and duration of exposure. Inclusion of human biomonitoring (HBM) data can improve RA hence providing a more accurate estimate of the body burden.
So far, RA have been carried out on some major mycotoxins from the public health perspective (i.e., aflatoxins, fumonisins, ochratoxin A, deoxynivalenol and zearalenone) by many international agencies and organizations (including the European Food Safety Authority (EFSA)) to set appropriate food safety regulation and recommendations. Two recent studies on the assessment of exposure to multiple mycotoxins of residents of an European (Portugal) and non-European (Brazil) country and characterisation of the associated risk will be presented and discussed as examples for risk assessment approaches based in occurrence in foods and urinary biomarkers.
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Keywords
Micotoxins Food Safety Risk Assessment Saúde Humana Segurança Alimentar Toxicologia Avaliação de Risco