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Maternal age and the prevalence of congenital heart defects in Europe, 1995–2015: A register‐based study

2023-02-03Journal article Open access
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dc.contributor.authorMamasoula, Chrysovalanto
dc.contributor.authorBigirumurame, Theophile
dc.contributor.authorChadwick, Thomas
dc.contributor.authorAddor, Marie‐Claude
dc.contributor.authorCavero‐Carbonell, Clara
dc.contributor.authorMatias Dias, Carlos
dc.contributor.authorEchevarría‐González‐de‐Garibay, Luis‐Javier
dc.contributor.authorGatt, Miriam
dc.contributor.authorKhoshnood, Babak
dc.contributor.authorKlungsoyr, Kari
dc.contributor.authorRandall, Kay
dc.contributor.authorStoianova, Sylvia
dc.contributor.authorHaeusler, Martin
dc.contributor.authorNelen, Vera
dc.contributor.authorNeville, Amanda J.
dc.contributor.authorPerthus, Isabelle
dc.contributor.authorPierini, Anna
dc.contributor.authorBertaut‐Nativel, Bénédicte
dc.contributor.authorRissmann, Anke
dc.contributor.authorRouget, Florence
dc.contributor.authorSchaub, Bruno
dc.contributor.authorTucker, David
dc.contributor.authorWellesley, Diana
dc.contributor.authorZymak‐Zakutnia, Natalya
dc.contributor.authorBarisic, Ingeborg
dc.contributor.authorde Walle, Hermien E.K.
dc.contributor.authorLanzoni, Monica
dc.contributor.authorSayers, Gerardine
dc.contributor.authorMullaney, Carmel
dc.contributor.authorPennington, Lindsay
dc.contributor.authorRankin, Judith
dc.date.accessioned2024-02-14T10:45:24Z
dc.date.available2024-02-14T10:45:24Z
dc.date.issued2023-02-03
dc.description.abstractBackground: Evidence on the direction and strength of association between maternal age and the prevalence of congenital heart defects (CHD) in different age group categories is conflicting. Some studies have illustrated different trends with an increase in prevalence in younger and older age groups while other studies have reported a linear relationship. Given the increase in maternal age over recent years, it is important to study the CHD prevalence by maternal age. Objectives: To examine the association between maternal age and the prevalence of CHD in Europe between 1995 and 2015 using population-based data from 24 registries belonging to the European Surveillance of Congenital Anomalies (EUROCAT) network. Methods: Associations over time of all nonsyndromic CHD according to maternal age category and for three CHD severity groupings (severity group I: very severe; severity group II: severe; severity group III: less severe) were examined using Bayesian multilevel Poisson regression modeling. Further subgroup analyses were undertaken within four maternal age-bands: ≤24, 25–29, 30–34 and 35–44 years. Descriptive summaries are also presented. Results: There were 51,608 nonsyndromic CHD cases in Europe over the 20-year study period. Total prevalence for all CHD combined was increased for younger mothers (≤24 years) and for mothers 35–44 years of age when compared with mothers aged 25–29 years (reference group) (IRR: 1.05, 95% CI: 1.02, 1.07). The total prevalence was increased for severity group I (very severe) only for younger mothers compared to those aged 25–29 years (IRR: 1.14, 95% CI: 1.04, 1.23). We found an increased prevalence of the following CHD subtypes: double outlet right ventricle (IRR:1.33, 95% CI: 1.09, 1.60), hypoplastic left heart syndrome (IRR: 1.18, 95% CI: 1.05, 1.32), hypoplastic right heart syndrome (IRR: 1.41, 95% CI: 1.05, 1.84), atrioventricular septal defect (IRR: 1.15, 95% CI: 1.01, 1.32), coarctation of aorta (IRR: 1.15, 95% CI: 1.03, 1.28) and atrial septal defect (IRR: 1.08, 95% CI: 1.02, 1.13). For older mothers (35–44 years) compared to the reference category, we observed an increased risk in the prevalence for severity group II (IRR: 1.09, 95% CI: 1.03, 1.14), severity group III (IRR: 1.05, 95% CI: 1.01, 1.08) and an increased prevalence of the CHD subtypes: Pulmonary valve stenosis (IRR: 1.22, 95% CI: 1.09, 1.34), ASD (IRR: 1.07, 95% CI: 1.02, 1.13), CoA (IRR: 1.18, 95% CI: 1.06, 1.32) and Tetralogy of Fallot (IRR: 1.14, 95% CI: 1.01, 1.28). Finally, for all age categories compared to the reference category, different associations of ASD and an increased prevalence of CoA was also observed. Conclusions: Based on data for cases of CHD from 24 European populationbased registries, evidence of a positive association between maternal age and the total prevalence of CHD for younger (≤24 years old) and older (35–44 years old) mothers was observed. The results suggest that young maternal age (≤24 years old) is a factor associated with severe CHD phenotypes while a positive association between advanced maternal age (35–44 years old) and mild CHD phenotypes was observed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBirth Defects Res. 2023 Apr 1;115(6):583-594. doi: 10.1002/bdr2.2152. Epub 2023 Feb 3.pt_PT
dc.identifier.doi10.1002/bdr2.2152pt_PT
dc.identifier.issn2472-1727
dc.identifier.urihttp://hdl.handle.net/10400.18/9102
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1002/bdr2.2152pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCongenital Heart Defectspt_PT
dc.subjectMaternal Agept_PT
dc.subjectPrevalencept_PT
dc.subjectEpidemiology Registriespt_PT
dc.subjectCongenital Anomaly Registrypt_PT
dc.subjectSurveillance Registriespt_PT
dc.subjectEUROCATpt_PT
dc.subjectEuropean Surveillance of Congenital Anomaliespt_PT
dc.subjectRegister-based Studypt_PT
dc.subjectEuropept_PT
dc.subjectEstados de Saúde e de Doençapt_PT
dc.titleMaternal age and the prevalence of congenital heart defects in Europe, 1995–2015: A register‐based studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage594pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage583pt_PT
oaire.citation.titleBirth Defects Researchpt_PT
oaire.citation.volume115pt_PT
person.familyNameMatias Dias
person.givenNameCarlos
person.identifier.ciencia-id6311-6117-ADEB
person.identifier.orcid0000-0002-0206-5874
person.identifier.ridI-6335-2012
person.identifier.scopus-author-id23103292400
rcaap.embargofctAcesso de acordo com página web do editor da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationfe9524e7-fc22-42f6-8eca-ab6a513ddd6b
relation.isAuthorOfPublication.latestForDiscoveryfe9524e7-fc22-42f6-8eca-ab6a513ddd6b

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