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CYP2D6 and IL-6 C-174G variants in schistosomiasis haematobia
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Resumo(s)
Aim: Study polymorphic variants in CYP2D6 and the C-174G promoter polymorphism of the IL-6
gene on S. haematobium infected patients from and endemic area of Guinea Bissau.
Background: - Schistosome egg associated catechol estrogens induce tumor-like phenotypes in urothelial cells and might cause schistosomiasis associated infertility (Botelho et al, Trends in Parasitol, 2015); - The cytochrome P450 (CYP) genes are involved in estrogen biosynthesis and metabolism and generation of DNA damaging procarcinogens (Blackburn et al, Cancer Causes and Control, 2015); - Very high or very low levels of IL-6 are associated with estrogen metabolism imbalance.
Descrição
Palavras-chave
Schistosomiasis Haematobia S. haematobium Infertility Guinea Bissau