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Exploring flagellar contributions to motility and virulence in Arcobacter butzleri
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Orientador(es)
Resumo(s)
Flagella is a well-known bacterial structure crucial for motility, which also plays pivotal roles in pathogenesis. Arcobacter butzleri, an enteropathogen, possesses a distinctive polar flagellum whose functional aspects remain largely unexplored. Upon investigating the factors influencing A. butzleri motility, we uncovered that environmental conditions like temperature, oxygen levels, and nutrient availability play a significant role. Furthermore, compounds that are found in human gut, such as short-chain fatty acids, mucins and bile salts, have a role in modulating the motility, and in turn, the pathogenicity of A. butzleri. Further investigation demonstrated that A. butzleri ΔflaA mutant showed a reduction in motility with a close to null average velocity, as well as a reduction on biofilm formation. In addition, compared with the wild-type, the ΔflaA mutant showed a decreased ability to invade Caco-2 cells and to adhere to mucins. Taken together, our findings support the role of environmental conditions and gut host associated compounds influencing key physiological aspects of the gastrointestinal pathogen A. butzleri, such as motility, and support the role of the flagellum on bacterial virulence.
Descrição
Palavras-chave
Arcobacter butzleri Environmental Conditions Flagellum Host Motility Virulence Infecções Gastrointestinais
Contexto Educativo
Citação
World J Microbiol Biotechnol. 2024 Oct 26;40(11):367. doi: 10.1007/s11274-024-04175-9
Editora
Springer