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New Class 2 Integron In2-4 Among IncI1-Positive Escherichia coli Isolates Carrying ESBL and PMAβ Genes from Food Animals in Portugal

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dc.contributor.authorJones-Dias, Daniela
dc.contributor.authorManageiro, Vera
dc.contributor.authorMartins, Ana P.
dc.contributor.authorFerreira, Eugénia
dc.contributor.authorCaniça, Manuela
dc.date.accessioned2016-03-22T17:24:58Z
dc.date.available2017-01-01T01:30:10Z
dc.date.issued2016
dc.description.abstractThe impact of extended-spectrum β-lactamases (ESBLs) and plasmid-mediated AmpC β-lactamases (PMAβs) of animal origin constitutes a public health concern. In this study, 179 Escherichia coli from food animals and products were analyzed, among which, 15 cephalosporin-resistant isolates harboring ESBL (CTX-M-1 [n = 8], CTX-M-14 [n = 1], SHV-12 [n = 2]) or PMAβ [CMY-2, n = 5]) were identified in poultry and swine, from different farms of distinct regions of Portugal. The multiple sequence-type IncI1-driven spread of ESBLs and PMAβs, flanked by widely disseminated mobile elements, was guaranteed by ST26/IncI1-harboring blaSHV-12, ST12/IncI1-harboring blaCMY-2, ST3 and ST38/IncI1-harboring blaCTX-M-1, and ST1/IncI1-harboring blaCTX-M-14. An IS10-disrupted In2-4, presenting a new attI2 recombination site, was also detected in a SHV-12/CTX-M-1-harboring isolate. This study highlights the fact that animals may act as persistent sources of ESBL- and PMAβ-harboring plasmids genes that might be transferred to humans through direct contact or via the food chain.pt_PT
dc.description.sponsorshipThis work was partially presented at the 23rd European Congress of Clinical Microbiology and Infectious Diseases in Berlin, Germany. This work was supported by Fundação para a Cência e a Tecnologia (FCT) for grant number PTDC/CVT/ 65713. We also thank the FCT for Project grant PEst-OE/ AGR/UI0211/2011-2014, Strategic Project UI211-2011-2014. D. Jones-Dias and V. Manageiro have received research funding from FCT (grant numbers SFRH/BD/80001/2011 and SFRH/ BPD/77486/2011).pt_PT
dc.identifier.citationFoodborne Pathog Dis. 2016 Jan;13(1):36-9. doi: 10.1089/fpd.2015.1972. Epub 2015 Nov 17.pt_PT
dc.identifier.doi10.1089/fpd.2015.1972pt_PT
dc.identifier.issn1535-3141
dc.identifier.urihttp://hdl.handle.net/10400.18/3721
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMary Ann Liebertpt_PT
dc.relation.publisherversionhttp://online.liebertpub.com/doi/abs/10.1089/fpd.2015.1972pt_PT
dc.subjectResistência aos Antimicrobianospt_PT
dc.subjectEscherichia colipt_PT
dc.subjectClass 2 Integronpt_PT
dc.subjectCTX-Mpt_PT
dc.subjectFood Animalspt_PT
dc.subjectPortugalpt_PT
dc.titleNew Class 2 Integron In2-4 Among IncI1-Positive Escherichia coli Isolates Carrying ESBL and PMAβ Genes from Food Animals in Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCVT%2F65713%2F2006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FAGR%2FUI0211%2F2014/PT
oaire.citation.endPage39pt_PT
oaire.citation.startPage36pt_PT
oaire.citation.titleFoodborne Pathogens and Diseasept_PT
oaire.citation.volume13(1)pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication1bb298ca-f838-4ad5-8808-861fd142046d
relation.isProjectOfPublicationd3e4188b-642e-4ad7-9a4d-aeea65a89449
relation.isProjectOfPublication.latestForDiscovery1bb298ca-f838-4ad5-8808-861fd142046d

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