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Mpox in People Living with HIV: Clinical Challenges, Preventive Strategies and Public Health Implications

2025-11-28Artigo científico Acesso aberto
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datacite.subject.fosCiências Médicas
dc.contributor.authorCordeiro, Rita
dc.contributor.authorCaria, J.
dc.contributor.authorSobral, D.
dc.contributor.authorPóvoas, D.
dc.contributor.editor.
dc.date.accessioned2026-02-06T15:52:39Z
dc.date.available2026-02-06T15:52:39Z
dc.date.issued2025-11-28
dc.description(This article belongs to the Special Issue Epidemiology of Zoonotic Virus Transmission: Pathways, Host Factors, and Public Health Strategies)
dc.description.abstractMonkeypox virus (MPXV) re-emerged in 2022 with a global outbreak that affected more than 100,000 individuals worldwide. People living with HIV (PLWH) accounted for a substantial proportion of cases, raising concerns about disease presentation, management, and outcomes in this population. Evidence indicates that PLWH with advanced or uncontrolled HIV infection experienced more severe mpox, with higher hospitalization rates, more complications, and longer disease courses. In contrast, individuals with well-controlled HIV generally had outcomes similar to those without HIV. Access to timely diagnosis, consistent antiretroviral therapy, and availability of tecovirimat were key factors influencing prognosis. Reports also suggest bidirectional interactions between mpox and HIV pathogenesis. Immune activation and APOBEC3-related viral evolution have been proposed; however, these mechanisms remain incompletely characterized and warrant further investigation. Moreover, disparities in healthcare access and stigma compound the vulnerability of PLWH, emphasizing the need for integrated approaches.eng
dc.identifier.citationViruses. 2025 Nov 28;17(12):1558. doi: 10.3390/v17121558
dc.identifier.doi10.3390/v17121558
dc.identifier.eissn1999-4915
dc.identifier.pmid41472229
dc.identifier.urihttp://hdl.handle.net/10400.18/10839
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relation.hasversionhttps://www.mdpi.com/1999-4915/17/12/1558
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectAntiviral Therapy
dc.subjectCo-Infection
dc.subjectMpox
dc.subjectPeople Living with HIV
dc.subjectPublic Health
dc.subjectVaccination
dc.subjectInfecções Sistémicas e Zoonoses
dc.titleMpox in People Living with HIV: Clinical Challenges, Preventive Strategies and Public Health Implicationseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage16
oaire.citation.issue12
oaire.citation.startPage1558
oaire.citation.titleViruses
oaire.citation.volume17
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCordeiro
person.givenNameRita
person.identifier.ciencia-idB518-A367-B8B7
person.identifier.orcid0000-0001-5321-3657
relation.isAuthorOfPublicationd94520e0-9d10-4302-af83-58afc79f152a
relation.isAuthorOfPublication.latestForDiscoveryd94520e0-9d10-4302-af83-58afc79f152a

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