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Publicação
Mpox in People Living with HIV: Clinical Challenges, Preventive Strategies and Public Health Implications
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Orientador(es)
Resumo(s)
Monkeypox virus (MPXV) re-emerged in 2022 with a global outbreak that affected more than 100,000 individuals worldwide. People living with HIV (PLWH) accounted for a substantial proportion of cases, raising concerns about disease presentation, management, and outcomes in this population. Evidence indicates that PLWH with advanced or uncontrolled HIV infection experienced more severe mpox, with higher hospitalization rates, more complications, and longer disease courses. In contrast, individuals with well-controlled HIV generally had outcomes similar to those without HIV. Access to timely diagnosis, consistent antiretroviral therapy, and availability of tecovirimat were key factors influencing prognosis. Reports also suggest bidirectional interactions between mpox and HIV pathogenesis. Immune activation and APOBEC3-related viral evolution have been proposed; however, these mechanisms remain incompletely characterized and warrant further investigation. Moreover, disparities in healthcare access and stigma compound the vulnerability of PLWH, emphasizing the need for integrated approaches.
Descrição
(This article belongs to the Special Issue Epidemiology of Zoonotic Virus Transmission: Pathways, Host Factors, and Public Health Strategies)
Palavras-chave
Antiviral Therapy Co-Infection Mpox People Living with HIV Public Health Vaccination Infecções Sistémicas e Zoonoses
Contexto Educativo
Citação
Viruses. 2025 Nov 28;17(12):1558. doi: 10.3390/v17121558
Editora
MDPI