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Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models

2023-01-24Journal article Open access
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dc.contributor.authorBessa, Maria João
dc.contributor.authorBrandão, Fátima
dc.contributor.authorRosário, Fernanda
dc.contributor.authorMoreira, Luciana
dc.contributor.authorReis, Ana Teresa
dc.contributor.authorValdiglesias, Vanessa
dc.contributor.authorLaffon, Blanca
dc.contributor.authorFraga, Sónia
dc.contributor.authorTeixeira, João Paulo
dc.date.accessioned2023-10-06T11:23:52Z
dc.date.available2023-10-06T11:23:52Z
dc.date.issued2023-01-24
dc.descriptionReviewpt_PT
dc.description.abstractSeveral studies have been conducted to address the potential adverse health risks attributed to exposure to nanoscale materials. While in vivo studies are fundamental for identifying the relation-ship between dose and occurrence of adverse effects, in vitro model systems provide important information regarding the mechanism(s) of action at the molecular level. With a special focus on exposure to inhaled (nano)particulate material toxicity assessment, this review provides an over-view of the available human respiratory models and exposure systems for in vitro testing, advan-tages, limitations, and existing investigations using models of different complexity. A brief overview of the human respiratory system, pathway and fate of inhaled (nano)particles is also presented.pt_PT
dc.description.sponsorshipThe work was supported by the Fundação para a Ciência e a Tecnologia [POCI-01-0145-FEDER-029651, SFRH/BPD/122112/2016,PTDC/MED‐TOX/31162/2017, DL-57/INSA06/2018,SFRH/BD/101060/2014,SFRH/BD/120646/2016, SIINN/0004/2014,UIDB/04750/2020, LA/P/0064/2020]; Spanish Ministry of Education, Culture and Sport [BEAGAL18/00142]; Spanish Ministry of Science and Innovation [PID2020-114908GA-I00].pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Toxicol Environ Health B Crit Rev. 2023 Feb 17;26(2):67-96. doi: 10.1080/10937404.2023.2166638. Epub 2023 Jan 24. Reviewpt_PT
dc.identifier.doi10.1080/10937404.2023.2166638pt_PT
dc.identifier.issn1093-7404
dc.identifier.urihttp://hdl.handle.net/10400.18/8666
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor and Francispt_PT
dc.relationA novelty study on the human uptake, genotoxicity and immunotoxicity of nanoparticles and legacy contaminants mixtures
dc.relationEstablishing grouping strategies according to toxicity and biological effects for silica based manufactured nanomaterials
dc.relationAssessing the toxicity of airborne nanoceramics in vitro and in vivo- contribution to the safe production and use of nanomaterials in the ceramic industry
dc.relationSAFE PRODUCTION AND USE OF NANOMATERIALS IN THE CERAMIC INDUSTRY
dc.relationEpidemiology Research Unit - Institute of Public Health, University of Porto
dc.relation.publisherversionhttps://www.tandfonline.com/doi/full/10.1080/10937404.2023.2166638pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectNanoparticlespt_PT
dc.subjectAir-liquid Interfacept_PT
dc.subjectIn vitropt_PT
dc.subjectRespiratory Modelspt_PT
dc.subjectSubmerged Culturespt_PT
dc.subjectToxicity Testingpt_PT
dc.subjectToxicologiapt_PT
dc.titleAssessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced modelspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleA novelty study on the human uptake, genotoxicity and immunotoxicity of nanoparticles and legacy contaminants mixtures
oaire.awardTitleEstablishing grouping strategies according to toxicity and biological effects for silica based manufactured nanomaterials
oaire.awardTitleAssessing the toxicity of airborne nanoceramics in vitro and in vivo- contribution to the safe production and use of nanomaterials in the ceramic industry
oaire.awardTitleSAFE PRODUCTION AND USE OF NANOMATERIALS IN THE CERAMIC INDUSTRY
oaire.awardTitleEpidemiology Research Unit - Institute of Public Health, University of Porto
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FMED-TOX%2F31162%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F122112%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F101060%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F120646%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/SIINN%2F0004%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04750%2F2020/PT
oaire.citation.endPage96pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage67pt_PT
oaire.citation.titleJournal of Toxicology and Environmental Health, Part B: Critical Reviewspt_PT
oaire.citation.volume26pt_PT
oaire.fundingStream9471 - RIDTI
oaire.fundingStreamOE
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
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rcaap.embargofctAcesso de acordo com a página web da revista.pt_PT
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