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Publication
Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models
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Advisor(s)
Abstract(s)
Several studies have been conducted to address the potential adverse health risks attributed to exposure to nanoscale materials. While in vivo studies are fundamental for identifying the relation-ship between dose and occurrence of adverse effects, in vitro model systems provide important information regarding the mechanism(s) of action at the molecular level. With a special focus on exposure to inhaled (nano)particulate material toxicity assessment, this review provides an over-view of the available human respiratory models and exposure systems for in vitro testing, advan-tages, limitations, and existing investigations using models of different complexity. A brief overview of the human respiratory system, pathway and fate of inhaled (nano)particles is also presented.
Description
Review
Keywords
Nanoparticles Air-liquid Interface In vitro Respiratory Models Submerged Cultures Toxicity Testing Toxicologia
Pedagogical Context
Citation
J Toxicol Environ Health B Crit Rev. 2023 Feb 17;26(2):67-96. doi: 10.1080/10937404.2023.2166638. Epub 2023 Jan 24. Review
Publisher
Taylor and Francis