Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models

Bessa, Maria João; Brandão, Fátima; Rosário, Fernanda; Moreira, Luciana; Reis, Ana Teresa; Valdiglesias, Vanessa; Laffon, Blanca; Fraga, Sónia; Teixeira, João Paulo

http://hdl.handle.net/10400.18/8666

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Autores

Valdiglesias, Vanessa

Laffon, Blanca

Fraga, Sónia

Teixeira, João Paulo

Resumo(s)

Several studies have been conducted to address the potential adverse health risks attributed to exposure to nanoscale materials. While in vivo studies are fundamental for identifying the relation-ship between dose and occurrence of adverse effects, in vitro model systems provide important information regarding the mechanism(s) of action at the molecular level. With a special focus on exposure to inhaled (nano)particulate material toxicity assessment, this review provides an over-view of the available human respiratory models and exposure systems for in vitro testing, advan-tages, limitations, and existing investigations using models of different complexity. A brief overview of the human respiratory system, pathway and fate of inhaled (nano)particles is also presented.