Publicação
Evaluation of chemopreventive effects of a hexanic extract prepared from Morinda citrifolia fruits
| dc.contributor.author | Torrejais, Joana | |
| dc.contributor.author | Pinhão, Mariana | |
| dc.contributor.author | Guidoti, David Teixeira | |
| dc.contributor.author | Silva, Maria João | |
| dc.date.accessioned | 2017-07-05T15:51:13Z | |
| dc.date.available | 2017-07-05T15:51:13Z | |
| dc.date.issued | 2017-05-08 | |
| dc.description.abstract | The identification of bioactive natural compounds that are able to reduce the deleterious health effects of toxicants is of utmost importance. One of these toxicants is patulin (PAT), a common mycotoxin affecting fruits’ integrity and representing a serious health concern. Morinda citrifolia (noni) is a tropical plant that has been used in traditional medicine mainly for its therapeutic properties. This work intended to explore the chemopreventive properties of the noni fruit, using an hexanic extract prepared and characterized in Brazil. The potential capacity of the noni extract to reduce the cytotoxic and genotoxic effects of three compounds with dissimilar modes of action – PAT, ethyl methanesulphonate (EMS) and hydrogen peroxide (H2O2) – was evaluated in a liver-derived human cell line (HepG2 cells) through the MTT and the Comet assays, respectively. The results showed that cells’ pre-exposure to the extract followed by co-exposure to PAT, EMS or H2O2 was able to significantly reduce the level of cytotoxicity and genotoxicity induced by the toxicants alone. When compared to caffeic acid, a recognized antioxidant, the noni extract revealed a capacity to reduce both patulinand H2O2-induced cytotoxicity, suggesting that its chemopreventive properties do not rely exclusively on an antioxidant potential. In conclusion, this study showed that the hexanic fraction of the Morinda citrifolia fruit displays a promising chemopreventive action against several toxic agents that deserves further investigation. The properties of other noni fruit fractions or extracts from other parts of the plant (e.g., leaves and roots) also need to be explored. | pt_PT |
| dc.description.sponsorship | Instituto Nacional de Saúde Doutor Ricardo Jorge (2016DGH1316), Fundação para a Ciência e Tecnologia (PTDC/DTP-FTO/0417/2012) and the Center of Biological Sciences, Maringá State University, Maringá, Brazil | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.18/4736 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | Morinda citrifolia Fruit | pt_PT |
| dc.subject | Patulin | pt_PT |
| dc.subject | Genotoxicity | pt_PT |
| dc.subject | Cytotoxicity | pt_PT |
| dc.subject | Genotoxicidade Ambiental | pt_PT |
| dc.title | Evaluation of chemopreventive effects of a hexanic extract prepared from Morinda citrifolia fruits | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.awardNumber | PTDC/DTP-FTO/0417/2012 | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FDTP-FTO%2F0417%2F2012/PT | |
| oaire.citation.conferencePlace | Lisboa, Portugal | pt_PT |
| oaire.citation.title | 2º Dia do Jovem Investigador do Instituto nacional de Saúde Doutor Ricardo Jorge, 8 maio 2017 | pt_PT |
| oaire.fundingStream | 3599-PPCDT | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
| relation.isProjectOfPublication | 7dee8a4a-7112-45ce-a8cb-8c552d7ae061 | |
| relation.isProjectOfPublication.latestForDiscovery | 7dee8a4a-7112-45ce-a8cb-8c552d7ae061 |