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Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis

2018-11-05Journal article Open access
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dc.contributor.authorCassini, Alessandro
dc.contributor.authorHögberg, Liselotte Diaz
dc.contributor.authorPlachouras, Diamantis
dc.contributor.authorQuattrocchi, Annalisa
dc.contributor.authorHoxha, Ana
dc.contributor.authorSimonsen, Gunnar Skov
dc.contributor.authorColomb-Cotinat, Mélanie
dc.contributor.authorKretzschmar, Mirjam E.
dc.contributor.authorDevleesschauwer, Brecht
dc.contributor.authorCecchini, Michele
dc.contributor.authorOuakrim, Driss Ait
dc.contributor.authorOliveira, Tiago Cravo
dc.contributor.authorStruelens, Marc J.
dc.contributor.authorSuetens, Carl
dc.contributor.authorMonnet, Dominique L.
dc.contributor.authorStrauss, Reinhild
dc.contributor.authorMertens, Karl
dc.contributor.authorStruyf, Thomas
dc.contributor.authorCatry, Boudewijn
dc.contributor.authorLatour, Katrien
dc.contributor.authorIvanov, Ivan N.
dc.contributor.authorDobreva, Elina G.
dc.contributor.authorTambic Andraševic, Arjana
dc.contributor.authorSoprek, Silvija
dc.contributor.authorBudimir, Ana
dc.contributor.authorPaphitou, Niki
dc.contributor.authorŽemlicková, Helena
dc.contributor.authorSchytte Olsen, Stefan
dc.contributor.authorWolff Sönksen, Ute
dc.contributor.authorMärtin, Pille
dc.contributor.authorIvanova, Marina
dc.contributor.authorLyytikäinen, Outi
dc.contributor.authorJalava, Jari
dc.contributor.authorCoignard, Bruno
dc.contributor.authorEckmanns, Tim
dc.contributor.authorAbu Sin, Muna
dc.contributor.authorHaller, Sebastian
dc.contributor.authorDaikos, George L.
dc.contributor.authorGikas, Achilleas
dc.contributor.authorTsiodras, Sotirios
dc.contributor.authorKontopidou, Flora
dc.contributor.authorTóth, Ákos
dc.contributor.authorHajdu, Ágnes
dc.contributor.authorGuólaugsson, Ólafur
dc.contributor.authorKristinsson, Karl G.
dc.contributor.authorMurchan, Stephen
dc.contributor.authorBurns, Karen
dc.contributor.authorPezzotti, Patrizio
dc.contributor.authorGagliotti, Carlo
dc.contributor.authorDumpis, Uga
dc.contributor.authorLiuimiene, Agne
dc.contributor.authorPerrin, Monique
dc.contributor.authorBorg, Michael A.
dc.contributor.authorde Greeff, Sabine C.
dc.contributor.authorMonen, Jos C.M.
dc.contributor.authorKoek, Mayke B.G.
dc.contributor.authorElstrøm, Petter
dc.contributor.authorZabicka, Dorota
dc.contributor.authorDeptula, Aleksander
dc.contributor.authorHryniewicz, Waleria
dc.contributor.authorCaniça, Manuela
dc.contributor.authorNogueira, Paulo Jorge
dc.contributor.authorFernandes, Paulo André
dc.contributor.authorManageiro, Vera
dc.contributor.authorPopescu, Gabriel A.
dc.contributor.authorSerban, Roxana I.
dc.contributor.authorSchréterová, Eva
dc.contributor.authorLitvová, Slavka
dc.contributor.authorŠtefkovicová, Mária
dc.contributor.authorKolman, Jana
dc.contributor.authorKlavs, Irena
dc.contributor.authorKorošec, Aleš
dc.contributor.authorAracil, Belén
dc.contributor.authorAsensio, Angel
dc.contributor.authorPérez-Vázquez, María
dc.contributor.authorBillström, Hanna
dc.contributor.authorLarsson, Sofie
dc.contributor.authorReilly, Jacqui S.
dc.contributor.authorJohnson, Alan
dc.contributor.authorHopkins, Susan
dc.date.accessioned2019-03-28T13:41:59Z
dc.date.available2019-03-28T13:41:59Z
dc.date.issued2018-11-05
dc.descriptionBurden of AMR Collaborative Group:National Institute of Health Dr Ricardo Jorge, Lisbon, Portugal (Prof M Caniça PhD, Vera Manageiro PhD)pt_PT
dc.descriptionFree PMC Article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300481/pt_PT
dc.description.abstractBackground: Infections due to antibiotic-resistant bacteria are threatening modern health care. However, estimating their incidence, complications, and attributable mortality is challenging. We aimed to estimate the burden of infections caused by antibiotic-resistant bacteria of public health concern in countries of the EU and European Economic Area (EEA) in 2015, measured in number of cases, attributable deaths, and disability-adjusted life-years (DALYs). Methods: We estimated the incidence of infections with 16 antibiotic resistance–bacterium combinations from European Antimicrobial Resistance Surveillance Network (EARS-Net) 2015 data that was country-corrected for population coverage. We multiplied the number of bloodstream infections (BSIs) by a conversion factor derived from the European Centre for Disease Prevention and Control point prevalence survey of health-care-associated infections in European acute care hospitals in 2011–12 to estimate the number of non-BSIs. We developed disease outcome models for five types of infection on the basis of systematic reviews of the literature. Findings: From EARS-Net data collected between Jan 1, 2015, and Dec 31, 2015, we estimated 671 689 (95% uncertainty interval [UI] 583 148–763 966) infections with antibiotic-resistant bacteria, of which 63·5% (426 277 of 671 689) were associated with health care. These infections accounted for an estimated 33 110 (28 480–38 430) attributable deaths and 874 541 (768 837–989 068) DALYs. The burden for the EU and EEA was highest in infants (aged <1 year) and people aged 65 years or older, had increased since 2007, and was highest in Italy and Greece. Interpretation: Our results present the health burden of five types of infection with antibiotic-resistant bacteria expressed, for the first time, in DALYs. The estimated burden of infections with antibiotic-resistant bacteria in the EU and EEA is substantial compared with that of other infectious diseases, and has increased since 2007. Our burden estimates provide useful information for public health decision-makers prioritising interventions for infectious diseases.pt_PT
dc.description.sponsorshipEuropean Centre for Disease Prevention and Controlpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLancet Infect Dis. 2019 Jan;19(1):56-66. doi: 10.1016/S1473-3099(18)30605-4. Epub 2018 Nov 5pt_PT
dc.identifier.doi10.1016/S1473-3099(18)30605-4pt_PT
dc.identifier.issn1473-3099
dc.identifier.urihttp://hdl.handle.net/10400.18/6333
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier/ Lancetpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1473309918306054?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAntibiotic-resistant Bacteriapt_PT
dc.subjectDeathspt_PT
dc.subjectDisability-adjusted life-yearspt_PT
dc.subjectEuropean Unionpt_PT
dc.subjectEuropean Economic Areapt_PT
dc.subjectResistência aos Antimicrobianospt_PT
dc.titleAttributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage66pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage56pt_PT
oaire.citation.titleLancet Infectious Diseasespt_PT
oaire.citation.volume19pt_PT
rcaap.embargofctPolítica editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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