Publication
Protein kinase-mediated regulation of glucose transporters translocation to the plasma membrane
| dc.contributor.author | Henriques, Andreia | |
| dc.contributor.author | Matos, Paulo | |
| dc.contributor.author | Jordan, Peter | |
| dc.date.accessioned | 2019-02-13T16:08:27Z | |
| dc.date.available | 2020-06-01T00:30:16Z | |
| dc.date.issued | 2018-09 | |
| dc.description.abstract | Cancer cells require increased glucose supply to sustain proliferation. One mechanism involves increased expression of glucose transporter (GLUT) genes. But insulin has revealed that protein phosphorylation is another key mechanism in glucose uptake regulation: insulin binding to responsive cells triggers a signalling cascade with phosphorylation of TBC1D4, a negative regulator of endosomal GLUT trafficking, so that more transporters are inserted into the plasma membrane. | pt_PT |
| dc.description.sponsorship | Support for this work was provided by FCT and BioISI with UID/MULTI/04046/2013 grant and PD BD 106080/2015 scholarship. | pt_PT |
| dc.description.version | info:eu-repo/semantics/draft | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.18/5795 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | WNK Protein Kinase | pt_PT |
| dc.subject | Cancer | pt_PT |
| dc.subject | Signal Transduction | pt_PT |
| dc.subject | Glucose | pt_PT |
| dc.subject | Vias de Transdução de Sinal e Patologias Associadas | pt_PT |
| dc.title | Protein kinase-mediated regulation of glucose transporters translocation to the plasma membrane | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04046%2F2013/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/WT/Immunology and Infectious Disease/106080 | |
| oaire.citation.conferencePlace | Lisboa, Portugal | pt_PT |
| oaire.citation.title | SINAL 2018- 9th international meeting on signal transduction, 21-22 September 2018 | pt_PT |
| oaire.fundingStream | 5876 | |
| oaire.fundingStream | Immunology and Infectious Disease | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/100010269 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Wellcome Trust | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
| relation.isProjectOfPublication | dc84f768-e6f2-4eea-b294-6c8ebbd1a156 | |
| relation.isProjectOfPublication | 6ccd41b5-e549-41a0-864f-6cea6266cbb2 | |
| relation.isProjectOfPublication.latestForDiscovery | dc84f768-e6f2-4eea-b294-6c8ebbd1a156 |