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Human biomonitoring in risk assessment: analysis of the current practice and 1st examples HBM in risk assessments of HBM4EU priority chemicals

2017-11-16Report Restricted access
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dc.contributor.authorSantonen, T.
dc.contributor.authorHeinälä, M.
dc.contributor.authorBessems, J.
dc.contributor.authorBuekers, J.
dc.contributor.authorCornelis, C.
dc.contributor.authorVermeire, T.
dc.contributor.authorWoutersen, M.
dc.contributor.authorvan Engelen, J.
dc.contributor.authorBorges, T.
dc.contributor.authorRousselle, C.
dc.contributor.authorOugier, E.
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorAlvito, Paula
dc.contributor.authorMartins, Carla
dc.contributor.authorAssunção, Ricardo
dc.contributor.authorSilva, Maria João Silva
dc.contributor.authorKrul, L.
dc.contributor.authorPronk, A.
dc.contributor.authorSchaddelee-Scholten, B.
dc.contributor.authorGonzalez, M.C.
dc.contributor.authorde Alba, M.
dc.contributor.authorDíaz, G.
dc.contributor.authorCastaño, A.
dc.contributor.authorViegas, S.
dc.contributor.authorHumar-Juric, T.
dc.contributor.authorKononenko, L.
dc.contributor.authorAbraham, K.
dc.contributor.authorVinggaard, A.M.
dc.date.accessioned2017-12-11T14:04:55Z
dc.date.available2017-12-11T14:04:55Z
dc.date.issued2017-11-16
dc.description.abstractIn chemicals risk assessment frameworks, the default approach is to assess external intake from different sources of exposure and via different routes of exposure. They are often assessed separately. This approach includes various uncertainties and often overestimates the real uptake since default, conservative estimates are used e.g. for the absorption of the chemical. At the same time, actual (real life) exposure may be underestimated by not taking into account that exposure to a chemical substance may occur from different sources, which may fall under separate legislative frameworks. Examples are triclosan that is used in biocidal products as well as in consumer products and importantly, most if not all chemicals that are produced by workers where at the same time these workers may be exposed as part of the general population. In some cases, other tools to assess exposure via all possible routes may be insufficient; an example is occupational exposure via hand-to-mount exposure, which has been shown to occur for example in the case of many metals, like lead, through contaminated hands. Without biomonitoring, exposure in these cases could become severely underestimated. Human Biomonitoring (HBM) is an important tool to survey the real life body burden – or internal exposure – of humans resulting from ‘total’ exposure to chemicals via different routes (lung, skin, digestive tract) and ‘via’ different legislative frameworks on chemicals. By providing more accurate data on actual body burdens (internal exposure), inclusion of HBM data could improve human health risk assessment for both the general population (exposure via air, consumer products, drinking water and food) as well as for workers (exposure via inhalation and/or skin) separately or as part of the population.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/4847
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.subjectHuman Biomonitoringpt_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.subjectToxicologia
dc.titleHuman biomonitoring in risk assessment: analysis of the current practice and 1st examples HBM in risk assessments of HBM4EU priority chemicalspt_PT
dc.typereport
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.titleDeliverable Report D 5.1- WP 5 - Translation of the results into the policypt_PT
oaire.fundingStreamH2020
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsrestrictedAccesspt_PT
rcaap.typereportpt_PT
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

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