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Angiogenesis in Schistosoma haematobium-associated urinary bladder cancer

2017-12Journal article Restricted access
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dc.contributor.authorDematei, A.
dc.contributor.authorFernandes, R.
dc.contributor.authorSoares, R.
dc.contributor.authorAlves, H.
dc.contributor.authorRichter, J.
dc.contributor.authorBotelho, M.C.
dc.date.accessioned2018-03-05T17:33:54Z
dc.date.available2018-09-29T00:30:11Z
dc.date.issued2017-12
dc.description.abstractSchistosoma haematobium, a parasitic flatworm that infects more than 100 million people, mostly in the developing world, is the causative agent of urogenital schistosomiasis, and is associated with a high incidence of squamous cell carcinoma (SCC) of the bladder. During infection, eggs are deposited in the bladder causing an intense inflammatory reaction. Angiogenesis is defined as the formation of new blood vessels from preexisting ones and is recognized as a key event in cell proliferation and carcinogenesis and spread of malignant lesions. A growing amount of evidence points to angiogenesis playing a key role in schistosomiasis-associated bladder cancer. Thus, identifying biomarkers of this process plays an important role in the study of cancer. Here, we review recent findings on the role of angiogenesis in bladder cancer and the growth factors that induce and assist in their development, particularly SCC of the bladder associated to urogenital schistosomiasis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAPMIS. 2017 Dec;125(12):1056-1062. doi: 10.1111/apm.12756. Epub 2017 Sep 28pt_PT
dc.identifier.doi10.1111/apm.12756pt_PT
dc.identifier.issn0903-4641
dc.identifier.issn1600-0463 (ESSN)
dc.identifier.urihttp://hdl.handle.net/10400.18/5177
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJohn Wiley & Sons Ltdpt_PT
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1111/apm.12756/abstract;jsessionid=9BDD911D5AC741EE0EBFC1A6235BE563.f03t01pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectSchistosomiasispt_PT
dc.subjectAngiogenic Markerspt_PT
dc.subjectBlood Vesselspt_PT
dc.subjectUrogenital Schistosomiasispt_PT
dc.subjectUrothelial Carcinomapt_PT
dc.titleAngiogenesis in Schistosoma haematobium-associated urinary bladder cancerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1062pt_PT
oaire.citation.issue12pt_PT
oaire.citation.startPage1056pt_PT
oaire.citation.titleAPMISpt_PT
oaire.citation.volume125pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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