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Obstructive Sleep Apnea: New insights into antioxidant activity and cellular response to stress

2015-09-28Conference object Open access
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dc.contributor.authorVaz, Fátima
dc.contributor.authorFeliciano, Amélia
dc.contributor.authorSilva, Ana Rita
dc.contributor.authorCoelho, Cristina
dc.contributor.authorTorres, Vukosava Millic
dc.contributor.authorBozanic, Vesna
dc.contributor.authorMalhotra, Atul
dc.contributor.authorPinto, Paula
dc.contributor.authorBárbara, Cristina
dc.contributor.authorPenque, Deborah
dc.date.accessioned2016-02-22T17:39:51Z
dc.date.available2016-02-22T17:39:51Z
dc.date.issued2015-09-28
dc.descriptionThis work was approved by the Ethical Committee of INSA.I.P.-Lisboa, Centro Hospitalar Lisboa-Norte., Faculdade de Ciências Médicas da Universidade Nova de Lisboa and Comissão Nacional de Proteção de Dados, Portugal.pt_PT
dc.descriptionDIGE images were obtained in ITQB.
dc.description.abstractObstructive sleep apnea (OSA) is a sleep¬related breathing disorder characterized by recurrent episodes of apnea/and hypopnea during sleep with resultant intermittent hypoxia and sleep fragmentation, leading to cardiometabolic diseases. OSA affects 3.7% to 26% of adult population, but frequently is underdiagnosed. By 2DIGE-proteomics approach, we have investigated red blood cells (RBC) in OSA to uncover new insights into putative chronic stress-induced RBC dysfunction that lead to inflammation and metabolic syndrome associated with OSA. A number of proteins as potential candidate biomarkers for OSA, such as the cytosolic antioxidant regulators, catalase (CAT) and peroxiredoxin2 (PRX2) was identified, needing additional biochemical research validation.pt_PT
dc.description.sponsorshipProject - Obstructive sleep apnea and associated metabolic/cardiovascular disorders: understanding mechanisms towards early diagnosis and prognosis prediction. Work partially supported by Harvard Medical School-Portugal Program (HMSP-ICJ/0022/2011), FCT/Poly-Annual Funding Program and FEDER/Saúde XXI Program (Portugal).pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/3459
dc.language.isoengpt_PT
dc.subjectAntioxidant Activitypt_PT
dc.subjectRed Blood Celolpt_PT
dc.subjectProteomicspt_PT
dc.subjectObstructive Aleep Apneiapt_PT
dc.subjectBiomarkerspt_PT
dc.subjectCardiometabolic Disorderspt_PT
dc.subjectDoenças Genéticaspt_PT
dc.subjectApneia Obstrutiva do Sonopt_PT
dc.titleObstructive Sleep Apnea: New insights into antioxidant activity and cellular response to stresspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/HMSP-ICJ%2F0022%2F2011/PT
oaire.citation.conferencePlaceLisboa, Portugalpt_PT
oaire.citation.titleScientific Toxomics Meeting, INSA, 28 setembro 2015pt_PT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublicationa9bad44d-3ec0-4cf1-acdc-ce4155e0f68a
relation.isProjectOfPublication.latestForDiscoverya9bad44d-3ec0-4cf1-acdc-ce4155e0f68a

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