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HBM4EU chromates study - Reflection and lessons learnt from designing and undertaking a collaborative European biomonitoring study on occupational exposure to hexavalent chromium

2021-05Journal article Open access
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dc.contributor.authorGalea, Karen S.
dc.contributor.authorPorras, Simo P.
dc.contributor.authorViegas, Susana
dc.contributor.authorBocca, Beatrice
dc.contributor.authorBousoumah, Radia
dc.contributor.authorDuca, Radu Corneliu
dc.contributor.authorGodderis, Lode
dc.contributor.authorIavicoli, Ivo
dc.contributor.authorJanasik, Beata
dc.contributor.authorJones, Kate
dc.contributor.authorKnudsen, Lisbeth E.
dc.contributor.authorLeese, Elizabeth
dc.contributor.authorLeso, Veruscka
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorNdaw, Sophie
dc.contributor.authorRuggieri, Flavia
dc.contributor.authorSepai, Ovnair
dc.contributor.authorScheepers, Paul T.J.
dc.contributor.authorSilva, Maria J.
dc.contributor.authorWasowicz, Wojciech
dc.contributor.authorSantonen, Tiina
dc.date.accessioned2022-01-10T15:40:24Z
dc.date.available2022-01-10T15:40:24Z
dc.date.issued2021-05
dc.descriptionMulticenter Studypt_PT
dc.description.abstractThe EU human biomonitoring initiative, HBM4EU, aims to co-ordinate and advance human biomonitoring (HBM) across Europe. As part of HBM4EU, we presented a protocol for a multicentre study to characterize occupational exposure to hexavalent chromium (Cr(VI)) in nine European countries (HBM4EU chromates study). This study intended to collect data on current occupational exposure and to test new indicators for chromium (Cr) biomonitoring (Cr(VI) in exhaled breath condensate and Cr in red blood cells), in addition to traditional urinary total Cr analyses. Also, data from occupational hygiene samples and biomarkers of early biological effects, including genetic and epigenetic effects, was obtained, complementing the biomonitoring information. Data collection and analysis was completed, with the project findings being made separately available. As HBM4EU prepares to embark on further European wide biomonitoring studies, we considered it important to reflect on the experiences gained through our harmonised approach. Several practical aspects are highlighted for improvement in future studies, e.g., more thorough/earlier training on the implementation of standard operating procedures for field researchers, training on the use of the data entry template, as well as improved company communications. The HBM4EU chromates study team considered that the study had successfully demonstrated the feasibility of conducting a harmonised multicentre investigation able to achieve the research aims and objectives. This was largely attributable to the engaged multidisciplinary network, committed to deliver clearly understood goals. Such networks take time and investment to develop, but are priceless in terms of their ability to deliver and facilitate knowledge sharing and collaboration.pt_PT
dc.description.abstractHighlights: Feasibility of conducting harmonised Pan-European biomonitoring study on occupational exposure demonstrated; Developing a successful network and implementation of systematic methodology takes significant dedication from all involved; Methodological improvements were identified which will benefit future large-scale occupational biomonitoring campaigns; Developed multicentre network allows and promotes further opportunities for future research, knowledge sharing and collaboration; Data produced supports science to policy interface in the scope of REACH and occupational safety and health regulations.pt_PT
dc.description.sponsorshipThis project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 733032 and received co-funding from the author’s organizations and/or Ministries.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J Hyg Environ Health. 2021 May;234:113725. doi: 10.1016/j.ijheh.2021.113725. Epub 2021 Mar 11pt_PT
dc.identifier.doi10.1016/j.ijheh.2021.113725pt_PT
dc.identifier.issn1438-4639
dc.identifier.urihttp://hdl.handle.net/10400.18/7839
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier/ Urban and Fischerpt_PT
dc.relationEuropean Human Biomonitoring Initiative
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1438463921000407?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectEnvironmental Genotoxicitypt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectOccupational Exposurept_PT
dc.subjectHexavalent chromiumpt_PT
dc.subjectStandard Operating Procedurept_PT
dc.subjectBiological Monitoringpt_PT
dc.subjectHarmonisationpt_PT
dc.subjectMethodologypt_PT
dc.subjectMulticentrept_PT
dc.subjectGenotoxicidade Ambientalpt_PT
dc.titleHBM4EU chromates study - Reflection and lessons learnt from designing and undertaking a collaborative European biomonitoring study on occupational exposure to hexavalent chromiumpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEuropean Human Biomonitoring Initiative
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/733032/EU
oaire.citation.startPage113725pt_PT
oaire.citation.titleInternational Journal of Hygiene and Environmental Healthpt_PT
oaire.citation.volume234pt_PT
oaire.fundingStreamH2020
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.embargofctAcesso de acordo com política editorial da revista.pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication6815dc2d-ef7e-4535-8dd3-5193c8bffba5
relation.isProjectOfPublication.latestForDiscovery6815dc2d-ef7e-4535-8dd3-5193c8bffba5

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