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Association study of the platelet collagen receptor glycoprotein VI gene with rheumatoid arthritis

2013-05-28Journal article Restricted access
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dc.contributor.authorMichou, L.
dc.contributor.authorCornélis, F.
dc.contributor.authorBaron, M.
dc.contributor.authorBombardieri, S.
dc.contributor.authorBalsa, A.
dc.contributor.authorWesthovens, R.
dc.contributor.authorBarrera, P.
dc.contributor.authorAlves, H.
dc.contributor.authorRadstake, T.R.
dc.contributor.authorMigliorini, P.
dc.contributor.authorBardin, T.
dc.contributor.authorPetit-Teixeira, E.
dc.contributor.authorBoilard, E.
dc.date.accessioned2014-10-30T12:30:22Z
dc.date.available2014-10-30T12:30:22Z
dc.date.issued2013-05-28
dc.descriptionH. Alves - INSA/Departamento Promoção da Saúde e Prevenção de Doenças Não Transmissíveis (Porto)por
dc.description.abstractBeyond their role in haemostasis, platelets can actively contribute to immunity. The activation of the platelet collagen receptor glycoprotein VI (GPVI) promotes the release of small extracellular vesicles called microparticles. These microparticles are found in the joint bathing fluid of patients with rheumatoid arthritis (RA) and are thought to amplify inflammation. The gene coding for GPVI is localised on chromosome 19q13.4 and contains different single nucleotide polymorphisms (SNPs). Five non-synonymous SNPs define the major and minor haplotypes of GPVI. The minor haplotype is associated with higher risk of cardiovascular incidents. In this study, we examined whether this minor haplotype is also associated with RA.por
dc.identifier.citationClin Exp Rheumatol. 2013 Sep-Oct;31(5):770-2. Epub 2013 May 28.por
dc.identifier.issn0392-856X
dc.identifier.urihttp://hdl.handle.net/10400.18/2409
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherClinical and Experimental Rheumatology Saspor
dc.relation.publisherversionhttp://www.clinexprheumatol.org/pubmed/find-pii.asp?pii=23739280por
dc.subjectPlateletspor
dc.subjectGlycoprotein VIpor
dc.subjectRheumatoid Arthritispor
dc.subjectSingle Nucleotidepor
dc.subjectPolymorphismpor
dc.subjectHaplotypepor
dc.titleAssociation study of the platelet collagen receptor glycoprotein VI gene with rheumatoid arthritispor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage772por
oaire.citation.startPage770por
oaire.citation.titleClinical and Experimental Rheumatologypor
oaire.citation.volume31(5)por
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor

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