Association study of the platelet collagen receptor glycoprotein VI gene with rheumatoid arthritis

Beyond their role in haemostasis, platelets can actively contribute to immunity. The activation of the platelet collagen receptor glycoprotein VI (GPVI) promotes the release of small extracellular vesicles called microparticles. These microparticles are found in the joint bathing fluid of patients with rheumatoid arthritis (RA) and are thought to amplify inflammation. The gene coding for GPVI is localised on chromosome 19q13.4 and contains different single nucleotide polymorphisms (SNPs). Five non-synonymous SNPs define the major and minor haplotypes of GPVI. The minor haplotype is associated with higher risk of cardiovascular incidents. In this study, we examined whether this minor haplotype is also associated with RA.

Descrição

H. Alves - INSA/Departamento Promoção da Saúde e Prevenção de Doenças Não Transmissíveis (Porto)

Palavras-chave

Platelets Glycoprotein VI Rheumatoid Arthritis Single Nucleotide Polymorphism Haplotype

URI

http://hdl.handle.net/10400.18/2409

Citação

Clin Exp Rheumatol. 2013 Sep-Oct;31(5):770-2. Epub 2013 May 28.

Editora

Clinical and Experimental Rheumatology Sas

Coleções

DPSPDNT - Artigos em revistas internacionais

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