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Interplay between glycemia and the genetics of ENOS and ACE genes for the susceptibility to the onset and development of hypertension on the Portuguese population

2020-11-20Conference object Open access
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dc.contributor.authorAguiar, Laura
dc.contributor.authorFerreira, Joana
dc.contributor.authorMatos, Andreia
dc.contributor.authorMascarenhas, Mário Rui
dc.contributor.authorMenezes Falcão, Luiz
dc.contributor.authorFaustino, Paula
dc.contributor.authorBicho, Manuel
dc.contributor.authorInácio, Ângela
dc.date.accessioned2021-03-13T15:53:08Z
dc.date.available2021-03-13T15:53:08Z
dc.date.issued2020-11-20
dc.description.abstractIntroduction: Hypertension is a multifactorial condition of anthropometric, physiologic, metabolic, genetic, and environmental nature. In Portugal, the mean prevalence of hypertension in the population is 45.5%. Objective: The aim of this study is to evaluate the contribution of anthropometric, physiological, and genetic factors (eNOS and ACE) to the development of hypertension in a Portuguese population. Methods: A case-control study was conducted in a sample of 377 individuals, 243 hypertensives, and 134 normotensives. The polymorphic analyses of intron 4 VNTR in the eNOS gene and the insertion/deletion (I/D) in ACE gene were performed by polymerase chain reaction (PCR). Results: High body mass index (BMI) values, high glycemia levels, and the 4a allele of the eNOS were associated with hypertension. Among the hypertensive group, the allele 4a (eNOS) was associated with high levels of HbA1c, and the D allele (ACE) with glycemia. Conclusion: Our results highlight the contribution of eNOS and ACE genes as important players for the onset and development of hypertension in the Portuguese population. We believe that a combinatory clinical approach including the traditional anthropomorphic and physiological parameters together with genetic studies can be more elucidative in establishing a susceptibility profile on multifactorial conditions as hypertension.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/7452
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectHypertensionpt_PT
dc.subjectGlycemiapt_PT
dc.subjectModificadores Genéticospt_PT
dc.subjectHipertensãopt_PT
dc.subjectDoenças Genéticaspt_PT
dc.titleInterplay between glycemia and the genetics of ENOS and ACE genes for the susceptibility to the onset and development of hypertension on the Portuguese populationpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceLisboa, Portugal (online)pt_PT
oaire.citation.title24ª Reunião Científica da Sociedade Portuguesa de Genética Humana, 20 novembro 2020pt_PT
person.familyNameFaustino
person.givenNamePaula
person.identifier.ciencia-idF01A-353A-433E
person.identifier.orcid0000-0002-6269-4867
person.identifier.ridM-3519-2014
person.identifier.scopus-author-id8158641100
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication94303e78-8b7d-4e24-811d-3af3b1a4e330
relation.isAuthorOfPublication.latestForDiscovery94303e78-8b7d-4e24-811d-3af3b1a4e330

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