Repository logo
 
Publication

Primary antibiotic resistance of Helicobacter pylori strains isolated from Portuguese children: a prospective multicentre study over a 10 year period

2011-10Journal article Restricted access
Simple item page
dc.contributor.authorOleastro, Mónica
dc.contributor.authorCabral, José
dc.contributor.authorRamalho, Paulo
dc.contributor.authorLemos, Piedade Sande
dc.contributor.authorBenoliel, João
dc.contributor.authorPaixão, Eleonorapor
dc.contributor.authorSantos, Andreapor
dc.contributor.authorLopes, Ana Isabelpor
dc.date.accessioned2012-02-14T17:18:17Z
dc.date.available2012-02-14T17:18:17Z
dc.date.issued2011-10
dc.description.abstractOBJECTIVES: The aim of this study was to prospectively assess the pattern of evolution of primary resistance to antibiotics in Helicobacter pylori strains isolated from Portuguese children over a 10 year period (2000-09). METHODS: A total of 1115 H. pylori strains were tested for antibiotic susceptibility to clarithromycin, metronidazole, amoxicillin, ciprofloxacin and tetracycline. RESULTS: H. pylori strains were isolated from children and adolescents [ages 4 months-18 years (mean age 10.17 ± 4.03 years)], comprising 562 (50.4%) boys and 553 (49.6%) girls. Overall, the primary resistance rate was 34.7% to clarithromycin, 13.9% to metronidazole and 4.6% to ciprofloxacin, while 6.9% were resistant to two of these antibiotics simultaneously. Resistance to amoxicillin and to tetracycline was not detected. In general, the resistance rate was not associated with gender or the children's age. European ethnicity, when compared with an African background, was associated with clarithromycin resistance [P = 0.002; odds ratio (OR) = 0.30; 95% confidence interval (CI) 0.14-0.66], while the inverse situation was observed for metronidazole (P < 0.001; OR = 3.50; 95% CI 1.90-6.45). No significant temporal trend was noticed for resistance to clarithromycin and metronidazole, whereas ciprofloxacin and double-resistance rates have significantly increased over time (P = 0.004 and P = 0.05, respectively). CONCLUSIONS: The primary resistance rate of H. pylori strains isolated from Portuguese children to the commonly used anti-H. pylori antibiotics used is high. Additionally, the increasing trend of ciprofloxacin-resistant and double-resistant strains may compromise H. pylori eradication in a high-prevalence population.por
dc.description.sponsorshipBNP Paribaspor
dc.identifier.citationJ Antimicrob Chemother. 2011 Oct;66(10):2308-11. Epub 2011 Jul 15por
dc.identifier.issnISSN: 0305-7453
dc.identifier.otherdoi: 10.1093/jac/dkr293
dc.identifier.urihttp://hdl.handle.net/10400.18/561
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherOxford University Presspor
dc.relation.publisherversionhttp://jac.oxfordjournals.org/content/66/10/2308.abstractpor
dc.subjectHelicobacter pyloripor
dc.subjectTemporal trendpor
dc.subjectPrimary antibiotic resistancepor
dc.subjectChildrenpor
dc.subjectPortugalpor
dc.subjectInfecções Gastrointestinaispor
dc.titlePrimary antibiotic resistance of Helicobacter pylori strains isolated from Portuguese children: a prospective multicentre study over a 10 year periodpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2311por
oaire.citation.startPage2308por
oaire.citation.titleJournal of Antimicrobial and Chemotherapypor
rcaap.rightsopenAccesspor
rcaap.typearticlepor

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Primary antibiotic resistance of Helicobacter pylori strains_2011.pdf
Size:
191.33 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

DDI - Artigos em revistas internacionais
DEP - Artigos em revistas internacionais