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Publicação
Genome-wide linkage analyses of quantitative and categorical autism subphenotypes
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Orientador(es)
Resumo(s)
The search for susceptibility genes in autism and autism spectrum disorders (ASD) has been hindered by the possible small effects of individual genes and by genetic (locus) heterogeneity. To overcome these obstacles, one method is to use autism-related subphenotypes instead of the categorical diagnosis of autism since they may be more directly related to the underlying susceptibility loci. Another strategy is to analyze subsets of families that meet certain clinical criteria to reduce genetic heterogeneity.
Descrição
Member of the Autism Genome Project Consortium: Astrid Moura Vicente
Palavras-chave
Autism Genetic heterogeneity IQ Language Linkage analysis Schizophrenia Perturbações do Desenvolvimento Infantil e Saúde Mental
Contexto Educativo
Citação
Biol Psychiatry. 2008 Oct 1;64(7):561-70. Epub 2008 Jul 16.