Genome-wide linkage analyses of quantitative and categorical autism subphenotypes

Liu, X.Q.; Paterson, A.D.; Szatmari, P.; Autism Genome Project Consortium

http://hdl.handle.net/10400.18/332

Use this identifier to reference this record.

Name:	Description:	Size:	Format:
Genome-wide Linkage Analyses of Quantitative and Categorical.pdf		682.84 KB	Adobe PDF	Download

Send Feedback

Authors

Liu, X.Q.

Paterson, A.D.

Szatmari, P.

Autism Genome Project Consortium

Abstract(s)

The search for susceptibility genes in autism and autism spectrum disorders (ASD) has been hindered by the possible small effects of individual genes and by genetic (locus) heterogeneity. To overcome these obstacles, one method is to use autism-related subphenotypes instead of the categorical diagnosis of autism since they may be more directly related to the underlying susceptibility loci. Another strategy is to analyze subsets of families that meet certain clinical criteria to reduce genetic heterogeneity.