Publicação
Introduction to hCOMET special issue, ‘Comet assay in vitro’
| dc.contributor.author | Dusinska, Maria | |
| dc.contributor.author | Costa, Solange | |
| dc.contributor.author | Collins, Andrew | |
| dc.date.accessioned | 2020-05-08T19:02:21Z | |
| dc.date.available | 2020-05-08T19:02:21Z | |
| dc.date.issued | 2019-07-03 | |
| dc.description | Editorial | pt_PT |
| dc.description.abstract | This special issue is produced as a valuable outcome of the COST Action hCOMET. A major aim of this project is to encourage the adoption of standard procedures for the comet assay, in order to improve reliability. Comet assay procedures tend to vary from one laboratory to another, and so comparing results between laboratories can be problematic. Much work has been done to establish how different parameters, such as agarose concentration, lysis time, or electrophoresis voltage gradient can affect results, and an aspiration of hCOMET is to devise standard procedures. In addition to papers on practical issues relating to the use of the comet assay, there are several descriptions of novel model cell systems. Finally, there are accounts of various applications of the assay to in vitro genotoxicity testing (mainly on human cell lines), as well as investigations of antigenotoxicity. (...) | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Mutat Res. 2019 Sep;845:403071. doi: 10.1016/j.mrgentox.2019.07.001. Epub 2019 Jul 3 | pt_PT |
| dc.identifier.doi | 10.1016/j.mrgentox.2019.07.001 | pt_PT |
| dc.identifier.issn | 0027-5107 | |
| dc.identifier.uri | http://hdl.handle.net/10400.18/6625 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.relation.publisherversion | https://www.sciencedirect.com/science/article/abs/pii/S1383571819302128?via%3Dihub | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | pt_PT |
| dc.subject | Animals | pt_PT |
| dc.subject | Biological Monitoring | pt_PT |
| dc.subject | Cell Line | pt_PT |
| dc.subject | Comet Assay | pt_PT |
| dc.subject | Humans | pt_PT |
| dc.subject | Laboratory Proficiency Testing | pt_PT |
| dc.subject | Reproducibility of Results | pt_PT |
| dc.title | Introduction to hCOMET special issue, ‘Comet assay in vitro’ | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.startPage | 403071 | pt_PT |
| oaire.citation.title | Mutation Research/Genetic Toxicology and Environmental Mutagenesis | pt_PT |
| oaire.citation.volume | 845 | pt_PT |
| rcaap.embargofct | De acordo com política editorial da revista. | pt_PT |
| rcaap.rights | embargoedAccess | pt_PT |
| rcaap.type | article | pt_PT |
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