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Editorial: Breakthroughs in top-down proteomics

2018-03Journal article Restricted access
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dc.contributor.authorPenque, Deborah
dc.contributor.authorMarcus, Katrin
dc.contributor.authorTorres, Vukosaca Milic
dc.date.accessioned2018-03-22T16:45:38Z
dc.date.available2021-03-21T01:30:11Z
dc.date.issued2018-03
dc.description.abstractIn this special issue, an updated overview on ‘where we are and where we are going in the area of top-down proteomics’ is given by Fornelli et al., one of the pioneering groups in top-down proteomics led by the proponent head of the term ‘proteoform’ and founder of the international Consortium in Top-Down Proteomics (CTDP), Neil Kelleher. Although being still technologically challenging, the rapid advances over the past years have demonstrated that the identification and characterization of thousands of proteoforms in high-throughput mode is today feasible for intact proteins< 30 kDa under denaturing condition. To further advance, the development of a new generation of instruments and softwares is still necessary, which may happen in the next coming years as predicted by the authors. The high molecular weight capability of native-top down proteomics, used today to characterize purified protein complexes under non-denaturing condition, is one of these technologies that could be innovated for high throughput top-down purposes. The main driver for this breakthrough is undoubtedly the wider acceptance and application of top-down approaches by proteomic researchers. This journey is already under way, as evidenced by the different articles presented in this special issue.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Proteomics. 2018 Mar 20;175:1-2. doi: 10.1016/j.jprot.2017.12.011. Epub 2017 Dec 21.pt_PT
dc.identifier.doi10.1016/j.jprot.2017.12.011pt_PT
dc.identifier.issn1874-3919
dc.identifier.urihttp://hdl.handle.net/10400.18/5435
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier/European Proteomics Association (EuPA)pt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1874391917304347?via%3Dihubpt_PT
dc.subjectProteomicspt_PT
dc.subjectBiomarkerspt_PT
dc.subjectGenómica Funcional e Estruturalpt_PT
dc.subjectGenómica Funcional
dc.titleEditorial: Breakthroughs in top-down proteomicspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleJournal of Proteomicspt_PT
oaire.citation.volume175pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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