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Publicação
Editorial: Breakthroughs in top-down proteomics
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Orientador(es)
Resumo(s)
In this special issue, an updated overview on ‘where we are and where we are going in the area of top-down proteomics’ is given by Fornelli et al.,
one of the pioneering groups in top-down proteomics led by the proponent head of the term ‘proteoform’ and founder of the international
Consortium in Top-Down Proteomics (CTDP), Neil Kelleher. Although being still technologically challenging, the rapid advances over the past years
have demonstrated that the identification and characterization of thousands of proteoforms in high-throughput mode is today feasible for intact
proteins< 30 kDa under denaturing condition. To further advance, the development of a new generation of instruments and softwares is still
necessary, which may happen in the next coming years as predicted by the authors. The high molecular weight capability of native-top down
proteomics, used today to characterize purified protein complexes under non-denaturing condition, is one of these technologies that could be
innovated for high throughput top-down purposes. The main driver for this breakthrough is undoubtedly the wider acceptance and application of
top-down approaches by proteomic researchers. This journey is already under way, as evidenced by the different articles presented in this special
issue.
Descrição
Palavras-chave
Proteomics Biomarkers Genómica Funcional e Estrutural Genómica Funcional
Contexto Educativo
Citação
J Proteomics. 2018 Mar 20;175:1-2. doi: 10.1016/j.jprot.2017.12.011. Epub 2017 Dec 21.
Editora
Elsevier/European Proteomics Association (EuPA)