Utility of salivary leucocytes for biomonitoring of human exposure to nanomaterials by means of the comet assay

Metal-based nanoparticles (NP) are being increasingly used in a wide variety of applications in consumer products and biomedical practices. As a result, human exposure to these nanomaterials is frequent, becoming a concern to public health. Human salivary leucocytes have been proposed as a proper biological sample for the comet assay, becoming an adequate non-invasive alternative model to evaluate DNA damage. In the present study, the suitability of salivary leucocytes to respond to exposure to different nanomaterials was addressed.

Palavras-chave

Metal-based Nanoparticles Comet Assay DNA Primary Damage DNA Oxidative Damage Metal Nanoparticles Salivary Leucocytes Genotoxicidade Ambiental Biomonitoring Human Exposure