Publication
New insights into how cancer cells regulate glucose uptake by protein phosphorylation
| dc.contributor.author | Henriques, Andreia | |
| dc.contributor.author | Jordan, Peter | |
| dc.date.accessioned | 2018-03-05T18:11:39Z | |
| dc.date.available | 2018-03-05T18:11:39Z | |
| dc.date.issued | 2017-05-08 | |
| dc.description.abstract | Cancer cells require increased glucose supply to sustain proliferation. One mechanism involves increased expression of glucose transporter (GLUT) genes. But insulin has revealed that protein phosphorylation is another key mechanism in glucose uptake regulation: insulin binding to responsive cells triggers a signalling cascade with phosphorylation of TBC1D4, a negative regulator of endosomal GLUT trafficking, so that more transporters are inserted into the plasma membrane. | pt_PT |
| dc.description.sponsorship | Funding Suport by FCT (BioISI grant UID/MULTI/04046/2013 and fellowship SFRH/PD/ BD/106080/2015). | pt_PT |
| dc.description.version | N/A | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.18/5189 | |
| dc.language.iso | eng | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | pt_PT |
| dc.subject | WNK Protein Kinase | pt_PT |
| dc.subject | Cancro | pt_PT |
| dc.subject | Transporte de Glucose | pt_PT |
| dc.subject | Vias de Transdução de Sinal e Patologias Associadas | pt_PT |
| dc.title | New insights into how cancer cells regulate glucose uptake by protein phosphorylation | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04046%2F2013/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/WT/Immunology and Infectious Disease/106080 | |
| oaire.citation.conferencePlace | Lisboa, Portugal | pt_PT |
| oaire.citation.title | 2º Dia do Jovem Investigador do Instituto Nacional de Saúde Doutor Ricardo Jorge, 8 maio 2017 | pt_PT |
| oaire.fundingStream | 5876 | |
| oaire.fundingStream | Immunology and Infectious Disease | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/100010269 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Wellcome Trust | |
| rcaap.rights | closedAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
| relation.isProjectOfPublication | dc84f768-e6f2-4eea-b294-6c8ebbd1a156 | |
| relation.isProjectOfPublication | 6ccd41b5-e549-41a0-864f-6cea6266cbb2 | |
| relation.isProjectOfPublication.latestForDiscovery | dc84f768-e6f2-4eea-b294-6c8ebbd1a156 |