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Occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in the European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE): a prospective, multinational study

2017-02Journal article Restricted access
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dc.contributor.authorGrundmann, Hajo
dc.contributor.authorGlasner, Corinna
dc.contributor.authorAlbiger, Barbara
dc.contributor.authorAanensen, David M.
dc.contributor.authorTomlinson, Chris T.
dc.contributor.authorAndrasević, Arjana Tambić
dc.contributor.authorCantón, Rafael
dc.contributor.authorCarmeli, Yehuda
dc.contributor.authorFriedrich, Alexander W.
dc.contributor.authorGiske, Christian G.
dc.contributor.authorGlupczynski, Youri
dc.contributor.authorGniadkowski, Marek
dc.contributor.authorLivermore, David M.
dc.contributor.authorNordmann, Patrice
dc.contributor.authorPoirel, Laurent
dc.contributor.authorRossolini, Gian M.
dc.contributor.authorSeifert, Harald
dc.contributor.authorVatopoulos, Alkiviadis
dc.contributor.authorWalsh, Timothy
dc.contributor.authorWoodford, Neil
dc.contributor.authorMonnet, Dominique L.
dc.contributor.authorEuSCAPE Working Group
dc.contributor.authorKoraqi, A..
dc.contributor.authorLacej, D.
dc.contributor.authorApfalter, P.
dc.contributor.authorHartl, R.
dc.contributor.authorGlupczynski, Y.
dc.contributor.authorHuang, T.D.
dc.contributor.authorStrateva, T
dc.contributor.authorMarteva-Proevska, Y.
dc.contributor.authorTambic, Andrasevic A.
dc.contributor.authorButic, I.
dc.contributor.authorPieridou-Bagatzouni, D.
dc.contributor.authorMaikanti-Charalampous, P.
dc.contributor.authorHrabak, J.
dc.contributor.authorZemlickova, H.
dc.contributor.authorHammerum, A.
dc.contributor.authorJakobsen, L.
dc.contributor.authorIvanova, M.
dc.contributor.authorPavelkovich, A.
dc.contributor.authorJalava, J.
dc.contributor.authorÖsterblad, M.
dc.contributor.authorDortet, L.
dc.contributor.authorVaux, S.
dc.contributor.authorKaase, M.
dc.contributor.authorGatermann, S.G.
dc.contributor.authorVatopoulos, A.
dc.contributor.authorTryfinopoulou, K.
dc.contributor.authorTóth, A.
dc.contributor.authorJánvári, L.
dc.contributor.authorBoo, T.W.
dc.contributor.authorMcGrath, E.
dc.contributor.authorCarmeli, Y.
dc.contributor.authorAdler, A.
dc.contributor.authorPantosti, A.
dc.contributor.authorMonaco, M.
dc.contributor.authorRaka, L.
dc.contributor.authorKurti, A.
dc.contributor.authorBalode, A.
dc.contributor.authorSaule, M.
dc.contributor.authorMiciuleviciene, J.
dc.contributor.authorMierauskaite, A.
dc.contributor.authorPerrin -Weniger, M.
dc.contributor.authorReichert, P.
dc.contributor.authorNestorova, N.
dc.contributor.authorDebattista, S.
dc.contributor.authorMijovic, G.
dc.contributor.authorLopicic, M.
dc.contributor.authorSamuelsen, Ø.
dc.contributor.authorHaldorsen, B.J.
dc.contributor.authorŻabicka, D.
dc.contributor.authorLiteracka, E.
dc.contributor.authorCaniça, M.
dc.contributor.authorManageiro, V.
dc.contributor.authorKaftandzieva, A.
dc.contributor.authorTrajkovska-Dokic, E.
dc.contributor.authorDamian, M.
dc.contributor.authorLixandru, B.
dc.contributor.authorJelesic, Z.
dc.contributor.authorTrudic, A.
dc.contributor.authorNiks, M.
dc.contributor.authorSchreterova, E.
dc.contributor.authorPirs, M.
dc.contributor.authorCerar, T.
dc.contributor.authorOteo, J.
dc.contributor.authorAracil, B.
dc.contributor.authorGiske, C.
dc.contributor.authorSjöström, K.
dc.contributor.authorGür, D.
dc.contributor.authorCakar, A.
dc.contributor.authorWoodford, N.
dc.contributor.authorHopkins, K.
dc.contributor.authorWiuff, C.
dc.contributor.authorBrown, D.J.
dc.date.accessioned2017-02-17T12:11:14Z
dc.date.available2017-11-19T01:30:14Z
dc.date.issued2017-02
dc.descriptionThe members of the European Survey on Carbapenemase-Producing Enterobacteriaceae, (EuSCAPE) Working Group are: Portugal—Manuela Caniça and Vera Manageiropt_PT
dc.description.abstractBACKGROUND: Gaps in the diagnostic capacity and heterogeneity of national surveillance and reporting standards in Europe make it difficult to contain carbapenemase-producing Enterobacteriaceae. We report the development of a consistent sampling framework and the results of the first structured survey on the occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in European hospitals. METHODS: National expert laboratories recruited hospitals with diagnostic capacities, who collected the first ten carbapenem non-susceptible clinical isolates of K pneumoniae or E coli and ten susceptible same-species comparator isolates and pertinent patient and hospital information. Isolates and data were relayed back to national expert laboratories, which made laboratory-substantiated information available for central analysis. FINDINGS: Between Nov 1, 2013, and April 30, 2014, 455 sentinel hospitals in 36 countries submitted 2703 clinical isolates (2301 [85%] K pneumoniae and 402 (15%) E coli). 850 (37%) of 2301 K pneumoniae samples and 77 (19%) of 402 E coli samples were carbapenemase (KPC, NDM, OXA-48-like, or VIM) producers. The ratio of K pneumoniae to E coli was 11:1. 1·3 patients per 10 000 hospital admissions had positive clinical specimens. Prevalence differed greatly, with the highest rates in Mediterranean and Balkan countries. Carbapenemase-producing K pneumoniae isolates showed high resistance to last-line antibiotics. INTERPRETATION: This initiative shows an encouraging commitment by all participants, and suggests that challenges in the establishment of a continent-wide enhanced sentinel surveillance for carbapenemase-producing Enterobacteriaeceae can be overcome. Strengthening infection control efforts in hospitals is crucial for controlling spread through local and national health care networks.pt_PT
dc.description.sponsorshipEuropean Centre for Disease Prevention and Controlpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLancet Infect Dis. 2017 Feb;17(2):153-163. doi: 10.1016/S1473-3099(16)30257-2. Epub 2016 Nov 18.pt_PT
dc.identifier.doi10.1016/S1473-3099(16)30257-2pt_PT
dc.identifier.issn1473-3099
dc.identifier.urihttp://hdl.handle.net/10400.18/4250
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier: Lancetpt_PT
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1473309916302572pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectEuSCAPEpt_PT
dc.subjectECDCpt_PT
dc.subjectCarbapenemase-producing Klebsiella pneumoniaept_PT
dc.subjectCarbapenemase-producing Escherichia colipt_PT
dc.subjectResistência aos Antimicrobianospt_PT
dc.titleOccurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in the European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE): a prospective, multinational studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage163pt_PT
oaire.citation.startPage153pt_PT
oaire.citation.titleThe Lancet Infectious Diseasespt_PT
oaire.citation.volume17(2)pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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