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Human biomonitoring of multiple mycotoxins in the Portuguese population: strengths and limitations under risk assessment

2019-10Conference object Restricted access
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dc.contributor.authorMartins, Carla
dc.contributor.authorDe Boevre, Marthe
dc.contributor.authorDe Saeger, Sarah
dc.contributor.authorNunes, Carla
dc.contributor.authorTorres, Duarte
dc.contributor.authorGoios, A.
dc.contributor.authorLopes, Carla
dc.contributor.authorAssunção, Ricardo
dc.contributor.authorAlvito, Paula
dc.contributor.authorVidal, A.
dc.date.accessioned2020-06-07T18:31:05Z
dc.date.available2020-06-07T18:31:05Z
dc.date.issued2019-10
dc.description.abstractMycotoxins constitute a relevant group of food contaminants with associated health outcomes such as estrogenic, immunotoxic, nephrotoxic and teratogenic effects. Although scarce data are available in Portugal, human biomonitoring (HBM) studies have been globally developed to assess the exposure to mycotoxins at individual level. This study aimed to present data for mycotoxins’ urinary biomarkers within a human biomonitoring study developed to assess the exposure of the Portuguese population, and to characterize the risk associated to the exposure. In the scope of the National Food, Nutrition, and Physical Activity Survey of the Portuguese General Population (2015-2016), 24h-urine samples from 94 participants were analyzed by liquid chromatography–mass spectrometry (LC-MS/MS) for the simultaneous determination of 37 mycotoxins’ urinary biomarkers. Data obtained were used to estimate the probable daily intake as well as the risk characterization applying multiple imputation, reverse dosimetry and hazard quotient approaches. Results revealed the exposure of Portuguese population to zearalenone, deoxynivalenol, ochratoxin A, alternariol, citrinin and fumonisin B1. Risk characterization data revealed a potential concern to some reported mycotoxins since the reference intake values were exceeded by some of the considered participants. The use of data at individual level, the collection of 24h urine samples, the performance of analytical method and the use of multiple imputation approach were identified as the main strengths of this study. The limitations identified were related with the use of excretion data obtained within animal studies and the absence of health based guidance values for urinary biomarkers that would allow a direct comparison. The present study generated, for the first time and within a HBM study, reliable data on internal exposure to multiple mycotoxins at individual level for the Portuguese population. These data contributes for supporting risk managers in the establishment of preventive policy measures to ensure public health protection.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.18/6957
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectMycotoxinspt_PT
dc.subjectHuman Biomonitoringpt_PT
dc.subjectPortugalpt_PT
dc.subjectSegurança Alimentarpt_PT
dc.subjectToxicologiapt_PT
dc.subjectAvaliação de Riscopt_PT
dc.subjectSaúde Humanapt_PT
dc.titleHuman biomonitoring of multiple mycotoxins in the Portuguese population: strengths and limitations under risk assessmentpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceLisboa, Portugalpt_PT
oaire.citation.title2nd Workshop on Human Biomonitoring in Portugal (2nd HBM-PT), 25 October 2019pt_PT
rcaap.rightsclosedAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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