Do nanoparticles induce neurodegenerative diseases? Understanding the origin of reactive oxidative species and protein aggregation and mis-folding phenomena in the presence of nanoparticles

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Organização

Publicações

Mutagenic and carcinogenic potential of metal nanoparticles depends on their physicochemical properties

Publication . Dusinska, Maria; El Yamani, Naouale; Fjellsbø, Lise Maria; Huk, Anna; Gabelova, Alena; Alonso, Tamara Iglesias; Silva, Maria João; Pran, Elise Runden

Nanomaterials (NMs) and nanoparticles (NPs) have been studied intensively for almost two decades and still all the characteristics that might be beneficial or harmful are not explored. Although many studies have investigated the mechanisms of action of NPs in cells, results are not fully understood and in many cases are controversial. Endpoints appropriate for detecting harmful chemicals such as cytotoxicity, oxidative stress, inflammation, immunotoxicity, genotoxicity, and in some cases carcinogenicity, have been addressed. However, there might be also new mechanisms that might lead to NM-induced toxic effects.

2016-06Documento de conferência

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Entidade financiadora

European Commission

Programa de financiamento

FP7

Número da atribuição

214547