Departamento de Genética Humana
Permanent URI for this community
Browse
Browsing Departamento de Genética Humana by contributor "Candeias, Marco M."
Now showing 1 - 1 of 1
Results Per Page
Sort Options
- p53 in Cancer and beyond - 40 Years after Its DiscoveryPublication . Candeias, Marco M.; Ohki, RiekoThe “p53 team” dictates cell fate and sacrifices cell life as demanded, for the greater good of the organism. The p53 team consists of its close family (p53, p63, and p73 genes), a varied number of isoforms, and a plethora of downstream target genes. Together they control cell stemness, division, chromosome integrity, epigenetics, differentiation, senescence and death; response to stress, infection and disease; reproduction, immunity, metabolism, and regeneration. As a consequence, p53 team function is central to our lives, from birth and development to aging and life span in both health and disease. Forty years after its discovery, we aim to cover important and new aspects of p53 and its team, not only in cancer, but in all the diversity of p53-dependent activities. Authors are invited to review recent work or submit original research in all areas of recent and current p53 research, with an emphasis on work providing molecular insight, including but not limited to novel physiological and pathological functions, or regulatory mechanisms.