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Percorrer INSA - Artigos em revistas internacionais por Domínios Científicos e Tecnológicos (FOS) "Ciências Agrárias::Ciências Veterinárias"
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- Glyphosate in the Iberian Peninsula: Evaluating risks to Iberian wildlifePublication . Baptista, Catarina Jota; Marques, Gonçalo Nogueira; Gonçalves, Luísa Lima; Assunção, Ricardo; Martinez-Haro, MónicaGlyphosate [N-(phosphonomethyl)glycine] (GlyP) is an herbicide extensively used worldwide, including the Iberian Peninsula. It is mainly used in agricultural landscapes but also in urban areas, in railways, and even in water bodies. Despite glyphosate’s large use, there is a paucity of research on its exposure and its potential effects on wildlife living treated environments. In recent years, an increasing number of studies have warned about the effects of this herbicide namely, on oxidative stress, and on liver and kidney in different taxa. Additionally, some studies also suggested endocrine disruption capacity in reptiles or genotoxicity in fish. Most of these studies have been carried out on experimental animals, in laboratory conditions, so the real exposure and potential effects on wildlife is largely unknown. In this context, this review is intended to help understand the ecological consequences that glyphosate may be exerting on wildlife that inhabit the Iberian Peninsula.
- Identification of a mouse-virulent recombinant type I/III Toxoplasma gondii strain in liver cytology of an immunosuppressed cat infected with FeLV-C subgroupPublication . Fonseca, Joana; Almeida, Pedro; Campos, Sónia; Borges, Vítor; Vilares, Anabela; Reis, Tânia; Gargaté, Maria João; Belas, AdrianaToxoplasma gondii infection is common in cats, though clinical disease is uncommon and typically occurs in immunocompromised individuals. Till now, there is no specific genotype that can be associated with a certain clinical outcome. A 5-year-old Siamese cat, diagnosed as Feline Leukemia Virus (FeLV)-positive and classified within the FeLV-C subgroup, presented with a two-month history of progressive lethargy, hyporexia, weight loss, and non-regenerative anemia. The cat, a rescued stray with ongoing outdoor access, had previously responded to doxycycline and prednisolone for presumed Mycoplasma spp. infection, but relapsed and began showing signs of discomfort in head and neck regions, consistent with peripheral neuropathy/ encephalitis. Despite treatment with raltegravir, prednisolone, darbopoetin alfa, cyclosporine and clindamycin (although unknown effectiveness of oral administration), clinical deterioration occurred. The cat developed fever, severe anemia, neutropenia, hyperbilirubinemia, hypoglycaemia and elevated ALT activity. Imaging revealed diffuse hepatic changes and a pulmonary interstitial pattern. Liver FNA identified T. gondii organisms, confirmed by qPCR. Despite the initiation of intravenous clindamycin and trimethoprim-sulfamethoxazole, the cat developed seizures, acute respiratory distress, and septic shock, leading to euthanasia. Genotyping of the hepatic T. gondii isolate via targeted NGS at 13 loci revealed a strain with a recombinant type I/III profile. This mosaicism was previously associated with high virulence in mice and also detected in human patients from the same geographical region. This case highlights the variable presentation of toxoplasmosis in cats and contributes to the scarce knowledge of circulating strains in animals. Characterizing the genetic background of strains could identify sources during zoonotic outbreaks and identify genotypes associated with specific clinical manifestations.