DGH - Apresentações orais em encontros internacionais
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- Chemicals in food: from toxicological research to regulatory challengesPublication . Silva, Maria JoãoCommunication on toxicological research and regulatory challenges related to chemicals in food.
- Fabry Newborn screening: challenges and risksPublication . Marcão, AnaCommunication about Challenges and Risks of Newborn Screening.
- FAIREHR: A Novel Online Research Registry PlatformPublication . Galea, Karen S.The FAIREHR (Findable, Accessible, Interoperable, Reusable Environmental and Health Registry) is a state-of-the-art online registry platform designed to enhance the transparency, reproducibility, and comparability of environmental health research, focusing on human biomonitoring (HBM) studies as a starting point. This platform is developed in response to the Europe Regional Chapter of the International Society of Exposure Science (ISES Europe) HBM working group strategic objectives to generate high quality HBM by harmonising the data life cycle and implementation of FAIR (findable, accessible, interoperable and reusable) guiding principles. The registry enables preregistration of studies, capturing key metadata on study design, data management, and planned methods before recruitment od the participants. FAIREHR is the first registry tailored for HBM studies and is also first registry promoting FAIR by design studies. Benefits of FAIREHR include increased research visibility, improved data comparability, enhanced collaboration, and better-informed decision-making. We will discuss the unique propositions of FAIREHR, emphasizing its role in enhancing the exchange of information, with its implementation expected to yield significant benefits for researchers, policymakers, and public health through effective utilization of HBM data.
- MIR-HBM: The Minimum Information Requirements Guidance for Human Biomonitoring StudiesPublication . Hopf, Nancy B.Background To fully understand the context, methods, data, and interpretations of a human biomonitoring (HBM) study, access to comprehensive background information is essential. However, the diversity in HBM study designs, coupled with varying levels of detail in the data collected, often makes meaningful comparisons, data reuse, and interpretation across different studies challanging. Materials and methods To address this need, the Minimum Information Requirements for Human Biomonitoring (MIR-HBM) was developed by the European Chapter of the International Society of Exposure Science (ISES Europe) HBM working group and the HBM Global Network. MIR-HBM describes the minimal set of information that must be provided to enable effective communication of the setup of an HBM study to others. It enables the generation of the metadata ('data about the data') that will cover all components of the study, including rationale and objectives, study population characteristics, biological specimen collection, laboratory analysis and method parameters, data analysis plan, data interpretation, and communication and reporting. Results Adherence to these reporting guidelines will result in publications of increased clarity,quality, comparability, and usefulness to the scientific community and other stakeholders. Integrating MIR-HBM as a FAIR metadata schema into the FAIREHR (Findable, Accessible, Interoperable, and Reusable Environmental and Health Registry) platform is the next key step planned to enable its implementation and adoption. Conclusions Overall, the MIR-HBM on HBM study metadata promotes transparency and completeness in reporting and enhances rapid capturing of the contents of the HBM study, thereby stimulating findability and accessibility to HBM data and supporting effective quality assessment.
- PARC Waste Management Survey: early health effects among workers from waste management industries in PortugalPublication . Tavares, Ana; Rosário, R.; Aimonen, K..; Louro, Henriqueta; Martins, Carla; Viegas, Susana; Santonen, T.; Silva, Maria João; PARC Waste Management Survey TeamIn a society increasingly generating waste, the Circular Economy Action Plan advocates for a more sustainable management of waste. Recycling of plastics and electronic devices (e-waste) is a rapidly growing sector, with more workers involved in tasks possibly favouring exposure to hazardous chemicals, (i.e. bisphenols, heavy metals, etc.). Under the framework of the European Partnership for the Assessment of Risks from Chemicals (PARC), a human biomonitoring study was developed on workers from plastic and e-waste recycling industries in European countries. In Portugal, workers involved in household plastic recycling and non-exposed individuals were included. Blood samples and demographic/lifestyle information were collected upon informed consent, and the cytokinesis-block micronucleus assay was performed in lymphocytes from 28 participants. The exposed group (n=18) presented significantly higher frequencies of micronucleated lymphocytes vs. controls (n=10) (p= 0.045). The same was observed for nuclear buds (p= 0.007) and nucleoplasmic bridges (p<0.001). However, no significant differences were observed between both groups regarding demographic/lifestyle variables. Our findings revealed genotoxic effects, possibly related with occupational exposure to e-waste and plastic waste. Such early effects indicate a possibility for future adverse health outcomes, such as cancer, if exposure continues. An assessment of levels of exposure to several substances among these workers is also currently underway. Such exposure data will allow us to analyse possible correlations between exposure levels and early biological effects, and infer on groups/tasks at higher risk, promoting risk management measures.
- Results and experiences on effect biomarkers in HBM4EU and PARC occupational studies – what recommendations can be given?Publication . Aimonen, Kukka; Silva, Maria João; Viegas, Susana; Scheepers, P.; Louro, Henriqueta; Martins, Carla; Duca, R.C.; Santonen, T.; HBM4EU; PARC occupational studies project groupsTable of content: -Selection criteria for biomarkers of effect in PARC (PARC – WP4: Roadmap Linking HBM and Health; Biomarkers of effect in HBM4EU and PARC Occupational studies); - Lessons learned (Considerations; Advantages; Challenges; Success stories from HBM4EU); - Validation and Regulatory integration.