Percorrer por data de Publicação, começado por "2023-09-27"
A mostrar 1 - 3 de 3
Resultados por página
Opções de ordenação
- Encouraging greater empowerment for adolescents in consent procedures in social science research and policy projectsPublication . Samdal, Oddrun; Budin‐Ljøsne, Isabelle; Haug, Ellen; Helland, Trond; Kjostarova‐Unkovska, Lina; Bouillon, Claire; Bröer, Christian; Corell, Maria; Cosma, Alina; Currie, Dorothy; Eriksson, Charli; Felder‐Puig, Rosemarie; Gaspar, Tania; Hagquist, Curt; Harbron, Janetta; Jåstad, Atle; Kelly, Colette; Knai, Cecile; Kleszczewska, Dorota; Kysnes, Bjarte Birkeland; Lien, Nanna; Luszczynska, Aleksandra; Moerman, Gerben; Moreno‐Maldonado, Concepcion; NicGabhainn, Saoirse; Pudule, Iveta; Rakic, Jelena Gudelj; Rito, Ana; Rønnestad, Alfred Mestad; Ulstein, Madeleine; Rutter, Harry; Klepp, Knut‐IngeThe United Nations Convention on the Rights of the Child emphasizes the importance of allowing children and adolescents to influence decisions that are important to them following their age and maturity. This paper explores the principles, practices, and implications around using parental versus child/adolescent consent when participating in social science research and policy development. Experiences from two studies are presented: The Confronting Obesity: Co-creating policy with youth (CO-CREATE) and the Health Behaviour in School-aged Children (HBSC) study, a World Health Organization (WHO) Collaborative Cross-National study. Although parental consent may be an important gatekeeper for protecting children and adolescents from potentially harmful research participation, it may also be considered an obstacle to the empowerment of children and adolescents in case they want to share their views and experiences directly. This paper argues that evaluation of possible harm should be left to ethics committees and that, if no harm related to the research participation processes is identified and the project has a clear perspective on collaborating with the target group, adolescents from the age of 12 years should be granted the legal capacity to give consent to participate in the research project. Collaboration with adolescents in the development of the research project is encouraged.
- The establishing of the program the human biomonitoring in the European Union - the portuguese perspetivePublication . Louro, HenriquetaThe portuguese perspetive about the establishing of the program the human biomonitoring in the European Union - the portuguese perspetive
- Development of Engineered-U1 snRNA Therapies: Current StatusPublication . Gonçalves, Mariana; Santos, Juliana Inês; Coutinho, Maria Francisca; Matos, Liliana; Alves, SandraSplicing of pre-mRNA is a crucial regulatory stage in the pathway of gene expression. The majority of human genes that encode proteins undergo alternative pre-mRNA splicing and mutations that affect splicing are more prevalent than previously thought. Targeting aberrant RNA(s) may thus provide an opportunity to correct faulty splicing and potentially treat numerous genetic disorders. To that purpose, the use of engineered U1 snRNA (either modified U1 snRNAs or exon-specific U1s-ExSpeU1s) has been applied as a potentially therapeutic strategy to correct splicing mutations, particularly those affecting the 5' splice-site (5'ss). Here we review and summarize a vast panoply of studies that used either modified U1 snRNAs or ExSpeU1s to mediate gene therapeutic correction of splicing defects underlying a considerable number of genetic diseases. We also focus on the pre-clinical validation of these therapeutic approaches both in vitro and in vivo, and summarize the main obstacles that need to be overcome to allow for their successful translation to clinic practice in the future.