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- Small GTPases in Cancer: Still Signaling the Way [Editorial]Publication . Matos, PauloExcerpt: In recent decades, many advances in the early diagnosis and treatment of cancer have been witnessed. However, cancerous diseases are still the second leading cause of death worldwide. Moreover, the incidence of cancer in the last three decades has nearly tripled and some estimates indicate that this may increase by five-fold by 2030 . Even more worrying, several epidemiological studies have indicated that the incidence of certain types of cancer is increasing sharply among young adults. [...]