Browsing by Issue Date, starting with "2018-04-24"
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- Two sisters with breast cancer before age 40: two different mutations?Publication . Rodrigues, Márcia; Bastos, Fernanda; Theisen-Pereira, Patrícia; Gonçalves, JoãoIntroduction: BRCA1- and BRCA2-associated hereditary breast and ovarian cancer (HBOC) syndrome should be suspected in individuals with a personal or family history of breast cancer diagnosed at or before age 50 years.
- Neglected aspects of tick-borne rickettsiosesPublication . Tomassone, L.; Portillo, A.; Nováková, M.; de Sousa, R.; Oteo, J.A.Rickettsioses are among the oldest known infectious diseases. In spite of this, and of the extensive research carried out, many aspects of the biology and epidemiology of tick-borne rickettsiae are far from being completely understood. Their association with arthropod vectors, the importance of vertebrates as reservoirs, the rarity of clinical signs in animals, or the interactions of pathogenic species with rickettsial endosymbionts and with the host intracellular environment, are only some examples. Moreover, new rickettsiae are continuously being discovered. In this review, we focus on the 'neglected' aspects of tick-borne rickettsioses and on the gaps in knowledge, which could help to explain why these infections are still emerging and re-emerging threats worldwide.